DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and abcg1

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001103924.1	Gene:	abcg1 / 556979	ZFINID:	ZDB-GENE-070424-84	Length:	673	Species:	Danio rerio

Alignment Length:	583	Identity:	196/583 - (33%)
Similarity:	324/583 - (55%)	Gaps:	29/583 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 KHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQAR 174
            |.|||.:.|....|.|:|:||.|||||:||:|.||.....|::    |..|:||.|.|.:..:..
Zfish   105 KTLLKGISGNFTGGALVAIMGPSGAGKSTLMNILAGYRETGMK----GEILINGHPRDLRSFRKV 165

  Fly   175 CAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVK 239
            ..|:.|||:.:..||.:|.::..|.:::......|:.:.|  :::..|.|.:|..|      |..
Zfish   166 SCYIMQDDMLLPHLTVQEAMMVSANLKLQEKDEGRREMVR--EILTALGLLECAKT------RTS 222

  Fly   240 GLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSEL 304
            .||||:|||||.|.|.:.:||::..|||||||||.:...||.::|.|:|.|:|||.||||||:::
Zfish   223 HLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSSSCFQVVSLMKALAQGGRTVICTIHQPSAKV 287

  Fly   305 FELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGREIESRDRIAK 369
            ||||||:.::::|:..:.|..|..:.:...:|..|||.:|||||   ::.|..|   |..|:.|:
Zfish   288 FELFDKLYVLSQGQCIYRGKVSSLIPYLRDLGLSCPTYHNPADF---IMEVASG---EYGDQTAR 346

  Fly   370 ICDNFAISKVARDMEQLLATKNLEKPL----------EQPENGYTYKATWFMQFRAVLWRSWLSV 424
            :.......|..:|.:..:....:..|.          ...|..:::.|:...||..:..|::||:
Zfish   347 LVKAVQEHKCEKDYKTEMNGNGVHNPFLWHRPSDEESSSSEGCHSFSASCLTQFCILFKRTFLSI 411

  Fly   425 LKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSEL 489
            :::.:|..:|::....:.|||||::||.......|::.:|.:|..:..:.|..:..|:..|..|:
Zfish   412 MRDSVLTHLRIMSHLGIGILIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEM 476

  Fly   490 PVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVLHFFNCLALVTLVAN 554
            .||:||..:..|....|:|.||:|::|..:..|:.:.:|.|.|....:..:.|...|||.||.:.
Zfish   477 GVFLREHLNYWYSLKAYYLAKTMADVPFQIVFPVAYCSIVYWMTSQPSDAVRFILFLALGTLTSL 541

  Fly   555 VSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLLI 619
            |:.|.|.||..||:|..:|..|||...||.|||.|||::..::|.||:|:||:|:.||..||:::
Zfish   542 VAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPKYLQWISYISYVRYGFEGVIL 606

  Fly   620 NQWADVEPGEISCTSSNTTCPSSGKVILETLNFSAADLPLDYVGLAILIVSFRVLAYLALRLR 682
            :.:. ::..::.|....|......:.||:.|:...|.|.:|::.|.|..:|.|::||..||.:
Zfish   607 SIYG-LDREDLHCDKDETCHFQKSEAILKELDVEDAKLYMDFIVLGIFFISLRLIAYFVLRYK 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	196/583 (34%)
abcg1	NP_001103924.1	3a01204	67..673	CDD:273361	196/583 (34%)
		ABCG_EPDR	81..306	CDD:213180	86/212 (41%)
		ABC2_membrane	403..605	CDD:279410	71/201 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574355
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.680