DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and st

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_524108.1	Gene:	st / 39836	FlyBaseID:	FBgn0003515	Length:	666	Species:	Drosophila melanogaster

Alignment Length:	645	Identity:	236/645 - (36%)
Similarity:	356/645 - (55%)	Gaps:	51/645 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SPPEDSGSGSGQLAENLTYAWHNMDIFGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNV 116
            ||.|          :..|..|.::.::  .|..|||.|.                   |.::.|.
  Fly    61 SPTE----------QGATLVWRDLCVY--TNVGGSGQRM-------------------KRIINNS 94

  Fly   117 CGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQD 181
            .|...||.|:|:|||||:|||||::.||||.|.|..|  .|..|:||:.: ...|.....||.||
  Fly    95 TGAIQPGTLMALMGSSGSGKTTLMSTLAFRQPAGTVV--QGDILINGRRI-GPFMHRISGYVYQD 156

  Fly   182 DLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGER 246
            |||:||||..|||.|.|.:|:.|.::..:|...:.::::...|.....|.||.....|.||||||
  Fly   157 DLFLGSLTVLEHLNFMAHLRLDRRVSKEERRLIIKELLERTGLLSAAQTRIGSGDDKKVLSGGER 221

  Fly   247 KRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFELFDKI 311
            ||||||.|.|.:|.:|.|||||:||||::|..:|..|.:|:|||.|::.|||||||:||:.|:.:
  Fly   222 KRLAFAVELLNNPVILFCDEPTTGLDSYSAQQLVATLYELAQKGTTILCTIHQPSSQLFDNFNNV 286

  Fly   312 LLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGREIESRDRIAKICDNFAI 376
            :|:|:|||||.|:|..|:.||:..|..||..||||||.:.|||..||.|..|:.....:||.||:
  Fly   287 MLLADGRVAFTGSPQHALSFFANHGYYCPEAYNPADFLIGVLATDPGYEQASQRSAQHLCDQFAV 351

  Fly   377 SKVARDMEQLLATKNLEKPLEQPENGYTYK--------ATWFMQFRAVLWRSWLSVLKEPLLVKV 433
            |..|:..:.|:   |||..:.|..| :.:.        ..|:.:|..|..|:.|::|::|.:..:
  Fly   352 SSAAKQRDMLV---NLEIHMAQSGN-FPFDTEVESFRGVAWYKRFHVVWLRASLTLLRDPTIQWL 412

  Fly   434 RLIQTTMVAILIGLIFLG-QQLTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSELPVFMREAR 497
            |.||...:|.:||..|.| .:.:|:||..:.||:|:.::..|:..:::.:|:|....|:||||.|
  Fly   413 RFIQKIAMAFIIGACFAGTTEPSQLGVQAVQGALFIMISENTYHPMYSVLNLFPQGFPLFMRETR 477

  Fly   498 SRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVLHFFNCLALVTLVANVSTSFGYL 562
            |.||....|:....:|.||..:..||:|..|.|.:.|||:....|......|.||.||:|:.|..
  Fly   478 SGLYSTGQYYAANILALLPGMIIEPLIFVIICYWLTGLRSTFYAFGVTAMCVVLVMNVATACGCF 542

  Fly   563 ISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLLINQWADVEP 627
            .|.|.:|..:|::...|:...|::..|.|:...|:||...|..:|||..||||.:...||:.|:
  Fly   543 FSTAFNSVPLAMAYLVPLDYIFMITSGIFIQVNSLPVAFWWTQFLSWMLYANEAMTAAQWSGVQ- 606

  Fly   628 GEISC--TSSNTTCPSSGKVILETLNFSAADLPLDYVGLAILIVSFRVLAYLALRLRARR 685
             .|:|  .|::..|..:|:.:|:..:|:.:::..:.:.:..|...|.:|.|..|..|||:
  Fly   607 -NITCFQESADLPCFHTGQDVLDKYSFNESNVYRNLLAMVGLYFGFHLLGYYCLWRRARK 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	233/629 (37%)
st	NP_524108.1	ABCG_EPDR	66..298	CDD:213180	110/255 (43%)
		3a01204	67..665	CDD:273361	232/627 (37%)
		ABC2_membrane	395..600	CDD:279410	70/204 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454589
Domainoid	1	1.000	116	1.000	Domainoid score	I1972
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	304	1.000	Inparanoid score	I769
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		mtm6474
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	10	9.900