DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and Atet

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001097079.1	Gene:	Atet / 33636	FlyBaseID:	FBgn0020762	Length:	832	Species:	Drosophila melanogaster

Alignment Length:	801	Identity:	214/801 - (26%)
Similarity:	354/801 - (44%)	Gaps:	201/801 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SKHPSAEHLNNGDSGA-----ASQSCINQG---FGQAKNYGTLR----PPSPPEDSGSGSGQLAE 66
            :.|.|..:|.||..|:     |.:...|.|   .||.|  ||:.    |..||.|
  Fly    92 NSHGSQNNLCNGGLGSNNHALAPKVANNSGGSPNGQKK--GTIALSHLPQRPPVD---------- 144

  Fly    67 NLTYAWHNMDIFGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGS 131
             :.:.    ||..:|..         :..||.           |.:||:|.|....||:.|:||.
  Fly   145 -IEFC----DISYSVTD---------SHRRGF-----------KTILKSVSGKFRNGEITAIMGP 184

  Fly   132 SGAGKTTLLNALA-FRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLI 195
            |||||:||:|.|| :::.|     .||..|:|.:..:.:..:....|:.|||:.|.:||.||.::
  Fly   185 SGAGKSTLMNILAGYKTAQ-----LSGSVLINSKERNLRRFRKLSCYIMQDDVLIANLTVREAMM 244

  Fly   196 FQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPP 260
            ..|.:::.:::....:|..|:::::.:.|.:..:|:      ...||||:||||:.|.|.:.:||
  Fly   245 VAANLKLGKNMISYAKVVVVEEILETIGLKESVNTL------TCNLSGGQRKRLSIALELVNNPP 303

  Fly   261 LLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTP 325
            ::..|||||||||.|...::.:|:.|::.|:|::.||||||:.|||.||.:.|:|:|:..:.|..
  Fly   304 VMFFDEPTSGLDSSTCFQLISLLRSLARGGRTIVCTIHQPSARLFEKFDHLYLLAQGQCVYEGRV 368

  Fly   326 SEAVDFFSYVGAQCPTNYNPADFYVQVL-------------AVVPG--REIESRDRI----AKIC 371
            ...|.:.|.:|.:||:.:||||:.::|.             ||..|  ::...:|.:    .|.|
  Fly   369 KGLVPYLSSLGYECPSYHNPADYVLEVASGEYGDAVPKLVDAVKSGACKKYAHKDYVLTLAQKGC 433

  Fly   372 DNFAISKVARDMEQLLATKNLE---KPLEQ----------------------------------- 398
            :|..|.......|..:|...||   .|||.
  Fly   434 NNDIIKGSGSGAENAMAILTLEDEKPPLEDRQLEPSIPVDDPAELKPPKLETQQSQNSDCSVVNM 498

  Fly   399 -------------------------------------------------------PENGYTYKAT 408
                                                                   |.:|:|
  Fly   499 PTNAVDDSCSFSSSKGTQNAVGGSGSGGPSAVVGCMTSLLDSHESVVTLPNKTGFPTSGWT---- 559

  Fly   409 WFMQFRAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGLIF--LGQQLTQVGVMNINGAIFLFLT 471
               ||..:|.||:.::|::.:|..:||....:|..:||:|:  :|.:.::  :|:..|.||....
  Fly   560 ---QFWILLKRSFRTILRDKMLTHMRLFSHVIVGAIIGMIYYDVGNEASK--IMSNAGCIFFVSL 619

  Fly   472 NMTFQNVFATINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAY-----P 531
            ..||..:..||..|.:|:.||:||..:..|....::..||||::|..:....|:..:.|     |
  Fly   620 FTTFTAMMPTILTFPTEMSVFVREHLNYWYSLKAFYFAKTIADMPFQIVFSSVYVLVVYYLTSQP 684

  Fly   532 MIGLRAGVLHFFNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGS 596
            |...|..:  |.....|.:|||.   |.|.||. |..:....:.:||...||.:||.|||:|..:
  Fly   685 MELERVSM--FVLICVLNSLVAQ---SLGLLIG-AGMNIETGVFLGPVTTIPTILFSGFFVNFDT 743

  Fly   597 VPVYLKWLSYLSWFRYANEGLLINQWADVEPGEISCTS--SNTTCPSSGKVILETLNFSAADLPL 659
            :|.||:|::|:|:.||..||.::..:. ::..::.|..  .:...|   |..||.::...|...:
  Fly   744 IPGYLQWVTYVSYVRYGFEGAMVAIYG-MDRAKMQCNQMYCHYRVP---KKFLEEMSMDNALFWV 804

  Fly   660 DYVGLAILIVSFRVLAYLALR 680
            |.|.|..:..:.|::||..||
  Fly   805 DAVALIGIFFALRIIAYFVLR 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	196/735 (27%)
Atet	NP_001097079.1	3a01204	137..825	CDD:273361	198/752 (26%)
		ABCG_EPDR	142..366	CDD:213180	86/269 (32%)
		ABC2_membrane	564..767	CDD:279410	67/210 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438917
Domainoid	1	1.000	79	1.000	Domainoid score	I2350
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		mtm14984
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	9	8.740