Protein Alignment w and Abcg2

DIOPT Version :10

• Sequence 1: NP_476787.1
• Gene: w / 31271
• FlyBaseID: FBgn0003996
• Length: 687
• Species: Drosophila melanogaster
• Sequence 2: NP_852046.1
• Gene: Abcg2 / 312382
• RGDID: 631345
• Length: 657
• Species: Rattus norvegicus
• Alignment Length: 663
• Identity: 207/663 - (31%)
• Similarity: 345/663 - (52%)
• Gaps: 70/663 - (10%)

  Fly    54 PEDSGSGSGQLAENLTYAWHNMDIFGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCG 118
            |..|..|:..|||....::|::.....|.   ||:  ||.:|            ..|.:|.::.|
  Rat    21 PGMSSRGARTLAEGDVLSFHHITYRVKVK---SGF--LVRKT------------AEKEILSDING 68

  Fly   119 VAYPGELLAVMGSSGAGKTTLLNALAFR-SPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQDD 182
            :..|| |.|::|.:|.||::||:.||.| .|:|:    ||..|:||.|..| ..:....||.|||
  Rat    69 IMKPG-LNAILGPTGGGKSSLLDVLAARKDPRGL----SGDVLINGAPQPA-NFKCSSGYVVQDD 127

  Fly   183 LFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERK 247
            :.:|:||.||:|.|.|.:|:|:.:...::..|::.:|:||.|.|...:.:|.. ..:|:||||||
  Rat   128 VVMGTLTVRENLQFSAALRLPKAMKTHEKNERINTIIKELGLDKVADSKVGTQ-FTRGISGGERK 191

  Fly   248 RLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFELFDKIL 312
            |.:...|.:|||.:|..||||:||||.||::|:.:||::|::|:|:|.:||||...:|:|||.:.
  Rat   192 RTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLT 256

  Fly   313 LMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVL-----AVVPGREIESRD------- 365
            |:|.|::.|.|...:|:::|:..|..|....|||||::.|:     ||:..|..:..:
  Rat   257 LLASGKLMFHGPAQKALEYFASAGYHCEPYNNPADFFLDVINGDSSAVMLNRGEQDHEANKTEEP 321

  Fly   366 --RIAKICDNFA--------ISKVARDMEQLLATKNLEKPLEQPENGYT------YKATWFMQFR 414
              |...|.:|.|        ..:...:::||        |:.|.:.|.:      |..::..|.|
  Rat   322 SKREKPIIENLAEFYINSTIYGETKAELDQL--------PVAQKKKGSSAFREPVYVTSFCHQLR 378

  Fly   415 AVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVF 479
            .:..||:.::|..|.....:||.|.::.::||.::.|.:....|:.|..|..|...||..|.:|.
  Rat   379 WIARRSFKNLLGNPQASVAQLIVTVILGLIIGALYFGLKNDPTGMQNRAGVFFFLTTNQCFTSVS 443

  Fly   480 ATINVFTSELPVFMREARSRLYRCDTYFLGKTIAE-LPLFLTVPLVFTAIAYPMIGLRAGVLHFF 543
            | :.:|..|..:|:.|..|..||..:||.||.::: ||:.....:::|.:.|.|:||:..|..||
  Rat   444 A-VELFVVEKKLFIHEYISGYYRVSSYFFGKLVSDLLPMRFLPSVIYTCLLYFMLGLKRTVEAFF 507

  Fly   544 NCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLS 608
            ..:..:.:||..::|....|:...|..|:|..:.....:..:||.|..:|..::..:|.||.|.|
  Rat   508 IMMFTLIMVAYTASSMALAIAAGQSVVSVATLLMTISFVFMMLFSGLLVNLRTIGPWLSWLQYFS 572

  Fly   609 WFRYANEGLLINQWADVE--PG-----EISCTSSNTTCPSSGKVILETLNFSAADLPLDYVGLAI 666
            ..||....|..|::...|  ||     ..:|.:|.|.|..:..:|.:.::.|...|..::|.||.
  Rat   573 IPRYGFTALQHNEFLGQEFCPGLNVTMNSTCVNSYTICTGNDYLINQGIDLSPWGLWRNHVALAC 637

  Fly   667 LIVSFRVLAYLAL 679
            :|:.|..:|||.|
  Rat   638 MIIIFLTIAYLKL 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	201/649 (31%)
Abcg2	NP_852046.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		1/3 (33%)
		3a01204	46..651	CDD:273361	200/638 (31%)