DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment w and Abca7

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_997481.1	Gene:	Abca7 / 299609	RGDID:	1303134	Length:	2170	Species:	Rattus norvegicus

Alignment Length:	224	Identity:	69/224 - (30%)
Similarity:	105/224 - (46%)	Gaps:	29/224 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 RKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQA 173
            |...:.::|....|||...::|.:|||||:     .||...|..:..||..:|.|..| |:|..|
  Rat  1831 RSPAVDHLCLGIPPGECFGLLGVNGAGKTS-----TFRMVTGDTLPSSGEAVLAGHNV-AQEPSA 1889

  Fly   174 ---RCAYVQQDDLFIGSLTAREHL-IFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGV 234
               ...|..|.|.....||.|||| :|..:..:|.        |:|.|.    :||....  :|:
  Rat  1890 AHRSMGYCPQSDAIFDLLTGREHLELFARLRGVPE--------AQVAQT----ALSGLVR--LGL 1940

  Fly   235 PG---RVKG-LSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVIL 295
            |.   |..| .|||.:::||.|...:.||.::..||||:|:|......:...|..:.::|::|:|
  Rat  1941 PSYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNNLLSVVREGRSVVL 2005

  Fly   296 TIHQPSSELFELFDKILLMAEGRVAFLGT 324
            |.|. ..|...|..::.:|..||...||:
  Rat  2006 TSHS-MEECEALCTRLAIMVNGRFRCLGS 2033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	69/224 (31%)
Abca7	NP_997481.1	rim_protein	1..2127	CDD:130324	69/224 (31%)
		ABC2_membrane	<557..742	CDD:304374
		ABC_subfamily_A	805..1024	CDD:213230
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1086
		ABC_subfamily_A	1818..2038	CDD:213230	69/224 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2129..2170
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000