DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and Abcg4

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_620405.3	Gene:	Abcg4 / 192663	MGIID:	1890594	Length:	646	Species:	Mus musculus

Alignment Length:	614	Identity:	213/614 - (34%)
Similarity:	333/614 - (54%)	Gaps:	57/614 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 GSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQ 149
            |..||:     ||.           |.|||.:.|.....||:.:||.|||||:|.:|.||.....
Mouse    73 GPCWRK-----RGY-----------KTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRES 121

  Fly   150 GIQVSPSGMRLLNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVAR 214
            |::    |..|:||:|.:.:..:....|:.|||:.:..||..|.::..|.::    |:.:|.|.:
Mouse   122 GMK----GQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLK----LSEKQEVKK 178

  Fly   215 --VDQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAH 277
              |.:::..|.|..|.||      |...||||:|||||.|.|.:.:||::..|||||||||.:..
Mouse   179 ELVTEILTALGLMSCSHT------RTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCF 237

  Fly   278 SVVQVLKKLSQKGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTN 342
            .||.::|.|:..|:|||.||||||::|||:|||:.::::|:..|.|..:..:.:...:|..|||.
Mouse   238 QVVSLMKSLAHGGRTVICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTY 302

  Fly   343 YNPADFYVQVLAVVPG-------REIESRDRIAKICDNFAISKVARDMEQLLATKNLEKPLEQPE 400
            :|||||.::|.:...|       |.:::     .:| ..|..|.:....:|.|......|...|.
Mouse   303 HNPADFIIEVASGEYGDLNPMLFRAVQN-----GLC-TMAEKKSSPGKNELPAHCPTCPPELDPI 361

  Fly   401 NGYTYKATWFMQFRAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFL--GQQLTQVGVMNIN 463
            ..:|:..:...||..:..|::||:|::.:|..:|.:...::.:||||::|  |...::  |.|..
Mouse   362 ESHTFATSTLTQFCILFRRTFLSILRDTVLTHLRFMSHVLIGVLIGLLYLHIGDDASK--VFNNT 424

  Fly   464 GAIFLFLTNMTFQNVFATINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAI 528
            |.:|..:..:.|..:..|:..|..|:.|||||..:..|....|:|.||:|::|..:..|:|:.:|
Mouse   425 GFLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYTLKAYYLAKTMADVPFQVVCPVVYCSI 489

  Fly   529 AYPMIGLRAGVLHF--FNCLALVTLVANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFF 591
            .|.|.|..|....|  |:.||:.|  |.|:.|.|.||..||:|..:|..|||...||.|||.|||
Mouse   490 VYWMTGQPAETSRFLLFSALAIAT--ALVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFF 552

  Fly   592 LNSGSVPVYLKWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTCP-SSGKVILETLNFSAA 655
            ::..::|.||:|.||||:.||..|||::..:. :|.|.::|....  || ...::||..|:...|
Mouse   553 VSFKTIPTYLQWSSYLSYVRYGFEGLILTIYG-MERGHLTCLDEQ--CPFRDPQIILRELDVEEA 614

  Fly   656 DLPLDYVGLAILIVSFRVLAYLALRLRAR 684
            .|.:|::.|.|..::.|:||||.||.|.:
Mouse   615 KLYMDFLVLGIFFLALRLLAYLVLRYRVK 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	213/614 (35%)
Abcg4	NP_620405.3	3a01204	44..646	CDD:273361	213/614 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831361
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.670