DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and wht-6

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_498425.2	Gene:	wht-6 / 188911	WormBaseID:	WBGene00007060	Length:	613	Species:	Caenorhabditis elegans

Alignment Length:	578	Identity:	214/578 - (37%)
Similarity:	346/578 - (59%)	Gaps:	14/578 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 RKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQA 173
            ::.|||||.|.|..|||||:||:||||||||||.|..|:.:|:  |..|...:||..: |.::.:
Worm    47 KRLLLKNVSGYAKSGELLALMGASGAGKTTLLNMLMCRNLKGL--STEGTITVNGNEM-AHKISS 108

  Fly   174 RCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRV 238
            ...:.||::||:|:||.:|:|:.||.:|:  :.:.:.|..||..|:.:|.|.||:.:.|||.|..
Worm   109 ISGFAQQEELFVGTLTVKEYLMIQAKLRI--NGSKKLREDRVTDVLHQLKLWKCRDSKIGVIGEK 171

  Fly   239 KGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSE 303
            ||:||||.:||.||.|.|::|.||..||||:|||||.|.||:|:||.:::.|:|:|.|||||||:
Worm   172 KGISGGEARRLTFACEMLSNPSLLFADEPTTGLDSFMAESVIQILKGIAKTGRTIICTIHQPSSQ 236

  Fly   304 LFELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGREIESRDRIA 368
            |:::|.:::.:|.|..||.|||.|::.||...|.:.|..|||:::.:..|||.||:|.:|.|||.
Worm   237 LYQMFHRVIYLANGSTAFQGTPQESISFFEKCGHRVPDEYNPSEWIIYKLAVQPGQEKQSNDRIQ 301

  Fly   369 KICDNFAIS-KVARDMEQLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWRSWLSVLKEPLLVK 432
            ||.:.:..| ...|.||||   .::.:.:..||   .::|..|.|..|:..|..:.|.:.|.|..
Worm   302 KIVEQYEDSDHQKRVMEQL---SDVSEKIPPPE---MHRANVFTQIFALSTRCGIDVWRAPQLTL 360

  Fly   433 VRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSELPVFMREAR 497
            .::||..:..:.|||::|.......|:.|||||:|.......:...:|.:....:|.|:..||..
Worm   361 AKVIQKILFGLFIGLLYLRTPYDARGIHNINGALFFLAGEYIYSTAYAIMFFLNNEFPLVAREYH 425

  Fly   498 SRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVLHFFNCLALVTLVANVSTSFGYL 562
            ..||...||:..:.|:.:|||.|..|:...|.|.:|||...|:.......:..|.:..:::||..
Worm   426 DGLYNLWTYYFARCISLIPLFSTDGLILLFIVYWLIGLNTSVMQVIVASIITVLASQAASAFGIA 490

  Fly   563 ISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLLINQWADVEP 627
            :||...:..|...:..|.::.|.||||.:.|:.:.|..::||.::|.:|:|.|||::|||::::
Worm   491 MSCIFPTAQMTAVMASPPLVLFRLFGGLYGNTNTFPAAIRWLQWISMYRFAFEGLVVNQWSEID- 554

  Fly   628 GEISCTSSNTTCPSSGKVILETLNFSAADLPLDYVGLAILIVSFRVLAYLALRLRARR 685
             :....:.|....|:...:|:...||.:.:|||.:||.::.::|.::.::||..|.::
Worm   555 -DFHSNAKNNWTNSTTNDVLDYFAFSESAIPLDIIGLILISLAFYLIGFIALVHRMKK 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	214/578 (37%)
wht-6	NP_498425.2	P-loop_NTPase	<3..>81	CDD:393306	24/33 (73%)
wht-6	NP_498425.2	3a01204	50..613	CDD:273361	214/575 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I3516
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49295
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760