DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and Abcg5

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_446206.2	Gene:	Abcg5 / 114628	RGDID:	620298	Length:	652	Species:	Rattus norvegicus

Alignment Length:	723	Identity:	198/723 - (27%)
Similarity:	334/723 - (46%)	Gaps:	136/723 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GSKHPSAEHLNNGDSGAASQSCINQGFGQAKNYGTLRPPSPPEDSGSGSGQLAENLTYAWHNMDI 77
            |::.|   |.|.|     |||.:.:|                  |.:||        .|.|::.:
  Rat    11 GARGP---HNNRG-----SQSSLEEG------------------SVTGS--------EARHSLGV 41

  Fly    78 ----FGAVNQPGSGWRQLVNRTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTT 138
                |...|:.|..|..       ..|.::.   .|| :||:|......|:.:.::||||:||||
  Rat    42 LNVSFSVSNRVGPWWNI-------KSCQQKW---DRK-ILKDVSLYIESGQTMCILGSSGSGKTT 95

  Fly   139 LLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQARCAYVQQDDLFIGSLTAREHLIFQAMVRMP 203
            ||:|::.|..:  ..:..|...:||..:...:.|...:|:.|.|:|:.|||.||.|.:.||
  Rat    96 LLDAISGRLRR--TGTLEGEVFVNGCELRRDQFQDCVSYLLQSDVFLSSLTVRETLRYTAM---- 154

  Fly   204 RHLTYRQRVA-----RVDQVIQELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLI 263
              |..|...|     :|:.|:.|||||.....:|| .....|:|.|||:|::.|::.|.||.:::
  Rat   155 --LALRSSSADFYDKKVEAVLTELSLSHVADQMIG-NYNFGGISSGERRRVSIAAQLLQDPKVMM 216

  Fly   264 CDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPSEA 328
            .||||:|||..||:.:|.:|.:|:::.:.||:|||||.||||..||||.::..|.:.|.|||.|.
  Rat   217 LDEPTTGLDCMTANHIVLLLVELARRNRIVIVTIHQPRSELFHHFDKIAILTYGELVFCGTPEEM 281

  Fly   329 VDFFSYVGAQCPTNYNPADFYVQVLAV---VPGREIESRDRIAKICDNFAISKVA-RDMEQLLAT 389
            :.||:..|..||.:.||.|||:.:.:|   ...||||:..|:..:...|..|.:. :.:|.:..|
  Rat   282 LGFFNNCGYPCPEHSNPFDFYMDLTSVDTQSREREIETYKRVQMLESAFRQSDICHKILENIERT 346

  Fly   390 KNLEK-PL-----EQPENGYTYKATWFMQFRAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGLI 448
            ::|:. |:     :.|..       .|.:...:|.|...::::...:|.:||:|..::.:.:...
  Rat   347 RHLKTLPMVPFKTKNPPG-------MFCKLGVLLRRVTRNLMRNKQVVIMRLVQNLIMGLFLIFY 404

  Fly   449 FLGQQ--LTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSELPVFMREARSRLYRCDTYFLGKT 511
            .|..|  :.:..|.:..|.::..:....:..:...:|:|.....|..:|::..||:.....|...
  Rat   405 LLRVQNNMLKGAVQDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQDGLYQKWQMLLAYV 469

  Fly   512 IAELPLFLTVPLVFTAIAYPMIGLRAGVLHF---------------FNCLALVTLV--ANVSTSF 559
            :..||..:...::|:::.|..:||...|..|               |..|.|:.:|  .|:..|.
  Rat   470 LHALPFSIVATVIFSSVCYWTLGLYPEVARFGYFSAALLAPHLIGEFLTLVLLGMVQNPNIVNSI 534

  Fly   560 GYLISCASSSTSMALSVGPPVIIPFLLFG-GFFLNSGSVPVYLKWLSYLSWFRYANEGLLINQWA 623
            ..|:|                 |..||.| ||..|...:|:.||.|.|.::.:|..|.|::|::.
  Rat   535 VALLS-----------------ISGLLIGSGFIRNIEEMPIPLKILGYFTFQKYCCEILVVNEFY 582

  Fly   624 DVEPGEISCTSSNTTCPSS-------GKVILE------TLNFSAADLPL-DYVGLAILI--VSFR 672
            .:   ..:|..|||:.|::       |...:|      |..|:...|.| .::...:::  |.|:
  Rat   583 GL---NFTCGGSNTSVPNNPMCSMTQGIQFIEKTCPGATSRFTTNFLILYSFIPTLVILGMVVFK 644

  Fly   673 VLAYLALR 680
            |..||..|
  Rat   645 VRDYLISR 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	186/668 (28%)
Abcg5	NP_446206.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		9/44 (20%)
		ABCG_White	50..276	CDD:213201	89/245 (36%)
		3a01204	61..646	CDD:273361	176/624 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7408
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920