DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment w and Abcg1

DIOPT Version :9

Sequence 1:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_033723.1	Gene:	Abcg1 / 11307	MGIID:	107704	Length:	666	Species:	Mus musculus

Alignment Length:	589	Identity:	198/589 - (33%)
Similarity:	328/589 - (55%)	Gaps:	33/589 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 KHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSPSGMRLLNGQPVDAKEMQAR 174
            |.|||.:.|....|||:|:||.|||||:||:|.||.....|::    |..|:||.|.|.:..:..
Mouse    98 KTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMK----GAVLINGMPRDLRCFRKV 158

  Fly   175 CAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRVK 239
            ..|:.|||:.:..||.:|.::..|.:::......|:.:  |.:::..|.|..|.:|      |..
Mouse   159 SCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREM--VKEILTALGLLPCANT------RTG 215

  Fly   240 GLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSEL 304
            .||||:|||||.|.|.:.:||::..|||||||||.:...||.::|.|:|.|::::.||||||::|
Mouse   216 SLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIVCTIHQPSAKL 280

  Fly   305 FELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVLAVVPGREIESRDRIAK 369
            |||||::.::::|:..:.|..|..|.:...:|..|||.:|||||   |:.|..|...:...|:.:
Mouse   281 FELFDQLYVLSQGQCVYRGKVSNLVPYLRDLGLNCPTYHNPADF---VMEVASGEYGDQNSRLVR 342

  Fly   370 -----ICDNFAISKVARDM------EQLLATKNLEKPLEQPENGYTYKATWFMQFRAVLWRSWLS 423
                 :||    :...||:      ...|..:..|:.....|..:::.|:...||..:..|::||
Mouse   343 AVREGMCD----ADYKRDLGGDTDVNPFLWHRPAEEDSASMEGCHSFSASCLTQFCILFKRTFLS 403

  Fly   424 VLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTFQNVFATINVFTSE 488
            ::::.:|..:|:.....:.:||||::||.......|::.:|.:|..:..:.|..:..|:..|..|
Mouse   404 IMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLE 468

  Fly   489 LPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVLHFFNCLALVTLVA 553
            :.||:||..:..|....|:|.||:|::|..:..|:.:.:|.|.|....:..:.|....||.|:.:
Mouse   469 MSVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTS 533

  Fly   554 NVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGSVPVYLKWLSYLSWFRYANEGLL 618
            .|:.|.|.||..||:|..:|..|||...||.|||.|||::..::|.||:|:||:|:.||..||::
Mouse   534 LVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPAYLQWMSYISYVRYGFEGVI 598

  Fly   619 INQWADVEPGEISCTSSNTTCPSSGKVILETLNFSAADLPLDYVGLAILIVSFRVLAYLALR--L 681
            ::.:. ::..::.|..:.|......:.||..|:...|.|.||::.|.|..:|.|::||..||  :
Mouse   599 LSIYG-LDREDLHCDIAETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKI 662

  Fly   682 RARR 685
            ||.|
Mouse   663 RAER 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	198/589 (34%)
Abcg1	NP_033723.1	3a01204	60..666	CDD:273361	197/587 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831350
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.680