Protein Alignment w and abcg8

DIOPT Version :10

• Sequence 1: NP_476787.1
• Gene: w / 31271
• FlyBaseID: FBgn0003996
• Length: 687
• Species: Drosophila melanogaster
• Sequence 2: XP_031758486.1
• Gene: abcg8 / 100498405
• XenbaseID: XB-GENE-981625
• Length: 682
• Species: Xenopus tropicalis
• Alignment Length: 691
• Identity: 206/691 - (29%)
• Similarity: 329/691 - (47%)
• Gaps: 100/691 - (14%)

  Fly    50 PPS---------PPEDSG-----SGSGQLAE--NLTY--------AWHNMDIFGAVNQPGSGWRQ 90
            |||         |.||:.     ||:..:.|  :|||        .|:  :.......|.. |.:
 Frog    22 PPSLRRNDDLYLPEEDNSLYFTYSGAPNVLEVKDLTYQVNLNAQIPWY--EKLAEFKMPWE-WNK 83

  Fly    91 LVNRTRGLFCNERHIPAPRKHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGIQVSP 155
                       :..|.|     :||:......|::|||:|::|.|||:||:.:..:. :|.::.
 Frog    84 -----------DGQISA-----MKNINVKVTSGQMLAVIGNTGCGKTSLLDIITCKD-EGGKIK- 130

  Fly   156 SGMRLLNGQPVDAKEMQARC-AYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVI 219
            ||..|:||: |..|....:| |:|:|||..:..||.||.|.|.|.:|:|:..:..||..:|:.||
 Frog   131 SGQILINGK-VSTKHRVKKCVAHVRQDDQLLPHLTVRETLTFIAKLRLPKSYSEEQRRRQVEDVI 194

  Fly   220 QELSLSKCQHTIIGVPGRVKGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLK 284
            .||.|.:|.:|.:| ....:|:|||||:|::...:.|.:|.:||.|||||||||||||::|..|.
 Frog   195 AELRLRQCANTKVG-NTYTRGVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVITLS 258

  Fly   285 KLSQKGKTVILTIHQPSSELFELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFY 349
            :|::..:.|:|:||||.|::|:|||.:||::.|...:.||..:.|::||.:|..||...||||||
 Frog   259 RLARGNRLVLLSIHQPRSDIFQLFDLVLLLSSGATIYSGTAKDMVEYFSSIGYPCPRYSNPADFY 323

  Fly   350 VQVLAV---VPGREIESRDRIAKICDNFAISKVARDMEQLL------ATKNL------------- 392
            |.:.::   ...||.||.:|...:.:.| ..|| :|.:..|      |.||:
 Frog   324 VDLTSIDQRNKERETESLERTRSLAEIF-WEKV-KDSDDFLWKPPGEANKNITPTNTSINLPVSA 386

  Fly   393 -EKPLEQPENGYTYKATWFMQFRAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQ 456
             ||.::...:..........||..:|.|...:.|::...:.:...:..::|:|||.::.||...|
 Frog   387 HEKAIKIKNSDMDQLPRGLHQFSVLLRRHVSNDLRDLSTLLIHGFEALVMALLIGFLYYGQGNNQ 451

  Fly   457 VGVMNINGAIFLFLTNMTFQNVFATINVFTSELPVFMREARSRLYRCDTYFLGKTIAELP----- 516
            :.:.:....:|:..:...|..|...:....||..:...:....||....||..|.|.|||
 Frog   452 LSIQDSIALLFMKGSLTPFAVVLDVVAKCHSERAMLYHDLEDGLYSVTPYFFAKVIGELPEHFAF 516

  Fly   517 -LFLTVPLVFTAIAYPMIGLRAGVLH---FFNCLALVTLVANVSTSFGYLISCASSSTSMALSVG 577
             :|..||:.:.|...|         |   |....||:.|:...|.:....:|....:..|:..:.
 Frog   517 VIFYGVPIYWLANLNP---------HPECFLLNFALLLLIVYCSRAMALWMSALLPTLQMSSFLS 572

  Fly   578 PPVIIPFLLFGGFFL---NSGSVPVYLKWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTC 639
            ..:.....|.|||.:   |..:||.   |:||:|:.|:..|||:..|:.|:   .......|.|.
 Frog   573 NAIFTSSYLTGGFIIRLENLWTVPY---WISYVSFLRWGFEGLMQVQFTDL---SYKVPVGNITI 631

  Fly   640 PSSGKVILETLNFSAADLPLDYVGLAILIVSFRVLAYLALR 680
            ...|..|:..:...:..|...|:.|..:|..|.||.||:||
 Frog   632 TIPGTAIISNMEMDSHPLYASYLVLIGIIAGFLVLYYLSLR 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
w	NP_476787.1	3a01204	68..687	CDD:273361	197/657 (30%)
abcg8	XP_031758486.1	3a01204	61..672	CDD:273361	192/650 (30%)