DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32795 and Tmem120a

DIOPT Version :9

Sequence 1:	NP_001245509.1	Gene:	CG32795 / 31270	FlyBaseID:	FBgn0040384	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_001010945.1	Gene:	Tmem120a / 288591	RGDID:	1311474	Length:	343	Species:	Rattus norvegicus

Alignment Length:	328	Identity:	162/328 - (49%)
Similarity:	222/328 - (67%)	Gaps:	4/328 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DSLKNEWEELNKEFAELESCNRRYIELLEQLHSHQQICFNEIKHQRYRMNQITTSLRQFKGPVPA 68
            |.|:| ||:|.::|..::..:|.|...||:|...|..|.|.|..|:.|:.::...|::.:..:|:
  Rat    11 DCLRN-WEDLQQDFQGIQETHRLYRVKLEELTKLQDNCTNSITRQKKRLQELALVLKKCRPSLPS 74

  Fly    69 EDKEKVDDLHKMTLKRKAQLHEIEQSLPAKSGRYLQIILGDVNVSILNRNDKVRYKDDYEKFKLI 133
            |..|...:|.....:|:....::|..||.|:|.||.::||:|||::|::..|..|||:||||||.
  Rat    75 ESLEAAQELESQIKERQGLFFDMEAYLPKKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLY 139

  Fly   134 LNVIGLIMAF-FNLIFNYRALELAFIFLLVWYYCTLTIRESILKVNGSRIKGWWRAHHFISTVAA 197
            |.:|.::::| ...:.|.|..:.||.|||||||||||||||||..|||||||||..||::||..:
  Rat   140 LTIILIVISFTCRFLLNSRVTDAAFNFLLVWYYCTLTIRESILINNGSRIKGWWVFHHYVSTFLS 204

  Fly   198 GVLLVWPQGEHWQIFRMQFMYFNVYISIVQYLQFGYQKGLLYRLKALGERHNMDITIEGFHSWMW 262
            ||:|.||.|..:|.||.||:.|::|.|.||:||:.||.|.||||:||||||.||:|:|||.||||
  Rat   205 GVMLTWPDGLMYQKFRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALGERHTMDLTVEGFQSWMW 269

  Fly   263 RGLSFLLPFLFIGYGYQAYNAWTLYKLAYSPPDAPWHVSVMSGL-FLLLFVGNMATTLWVVPEKI 326
            |||:|||||||.|:.:|.:||.||:.||..|....|.| :|.|| |||||:||..|||.||.:|.
  Rat   270 RGLTFLLPFLFFGHFWQLFNALTLFNLARDPECKEWQV-LMCGLPFLLLFLGNFFTTLRVVHQKF 333

  Fly   327 RER 329
            ..:
  Rat   334 HSQ 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32795	NP_001245509.1	TMPIT	7..329	CDD:285135	160/323 (50%)
Tmem120a	NP_001010945.1	TMPIT	13..336	CDD:285135	161/324 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353785
Domainoid	1	1.000	320	1.000	Domainoid score	I1199
eggNOG	1	0.900	-	-		E1_KOG4758
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12907
Inparanoid	1	1.050	322	1.000	Inparanoid score	I2425
OMA	1	1.010	-	-		QHG55657
OrthoDB	1	1.010	-	-		D398151at33208
OrthoFinder	1	1.000	-	-		FOG0002380
OrthoInspector	1	1.000	-	-		otm45698
orthoMCL	1	0.900	-	-		OOG6_103806
Panther	1	1.100	-	-	LDO	PTHR21433
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1574
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770