DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32795 and TMEM120B

DIOPT Version :9

Sequence 1:	NP_001245509.1	Gene:	CG32795 / 31270	FlyBaseID:	FBgn0040384	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_001074294.2	Gene:	TMEM120B / 144404	HGNCID:	32008	Length:	339	Species:	Homo sapiens

Alignment Length:	333	Identity:	156/333 - (46%)
Similarity:	223/333 - (66%)	Gaps:	2/333 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IDSLKNEWEELNKEFAELESCNRRYIELLEQLHSHQQICFNEIKHQRYRMNQITTSLRQFKGPVP 67
            ::..:.||.||..||.||:..:|.|.:.||:|.:.|.:|.:.|..|:..:..:..:|::.|....
Human     5 LERCEREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDLKLTLQRCKRHAS 69

  Fly    68 AEDKEKVDDLHKMTLKRKAQLHEIEQSLPAKSGRYLQIILGDVNVSILNRNDKVRYKDDYEKFKL 132
            .|:.|.|..:.....:|:....::|..||.|:|.||.::||:|||::|:...|..|||:||||||
Human    70 REEAELVQQMAANIKERQDVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKL 134

  Fly   133 ILNVIGLIMAF-FNLIFNYRALELAFIFLLVWYYCTLTIRESILKVNGSRIKGWWRAHHFISTVA 196
            .|.:|.|:.|. ...:.:||..:..|.|||||||||||||||||..|||||||||.:||::||..
Human   135 YLTIILLLGAVACRFVLHYRVTDEVFNFLLVWYYCTLTIRESILISNGSRIKGWWVSHHYVSTFL 199

  Fly   197 AGVLLVWPQGEHWQIFRMQFMYFNVYISIVQYLQFGYQKGLLYRLKALGERHNMDITIEGFHSWM 261
            :||:|.||.|..:|.||.||:.|:::.|.||:||:.||:|.||||:|||||:::|:|:|||.|||
Human   200 SGVMLTWPNGPIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALGERNHLDLTVEGFQSWM 264

  Fly   262 WRGLSFLLPFLFIGYGYQAYNAWTLYKLAYSPPDAPWHVSVMSGLFLLLFVGNMATTLWVVPEKI 326
            ||||:|||||||.|:.:|.|||.||::|:.......|.|.|::..||:||:||..|||.||..|:
Human   265 WRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLAFTFLILFLGNFLTTLKVVHAKL 329

  Fly   327 -RERAKER 333
             :.|.|.:
Human   330 QKNRGKTK 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32795	NP_001245509.1	TMPIT	7..329	CDD:285135	154/323 (48%)
TMEM120B	NP_001074294.2	TMPIT	9..332	CDD:311687	154/322 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159715
Domainoid	1	1.000	320	1.000	Domainoid score	I1241
eggNOG	1	0.900	-	-		E1_KOG4758
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2523
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55657
OrthoDB	1	1.010	-	-		D398151at33208
OrthoFinder	1	1.000	-	-		FOG0002380
OrthoInspector	1	1.000	-	-		otm41574
orthoMCL	1	0.900	-	-		OOG6_103806
Panther	1	1.100	-	-	O	PTHR21433
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3603
SonicParanoid	1	1.000	-	-		X1574
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800