Protein Alignment Syx4 and STX19

DIOPT Version :10

• Sequence 1: NP_525057.2
• Gene: Syx4 / 31269
• FlyBaseID: FBgn0024980
• Length: 333
• Species: Drosophila melanogaster
• Sequence 2: NP_001001850.1
• Gene: STX19 / 415117
• HGNCID: 19300
• Length: 294
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 58/321 - (18%)
• Similarity: 132/321 - (41%)
• Gaps: 61/321 - (19%)

  Fly     3 KDRLPELLQRSLSTNSSNSSSNGSLLLNVYSGTTEFIIGNTGGNNNSYSVVSQNSHSCSNNNSST 67
            ||||.||.||:....                                   :|::||.     |:|
Human     2 KDRLQELKQRTKEIE-----------------------------------LSRDSHV-----STT 26

  Fly    68 EPKDR----SSSKMTQYGSNVDDILNPYTEIRQQLAQIAANLETMNRMAQTV--NLRTFNENEMD 126
            |.:::    ..:.:.:.....:..|:...::::.:..:|.|::...:..:::  ::|.|:..:.:
Human    27 ETEEQGVFLQQAVIYEREPVAERHLHEIQKLQESINNLADNVQKFGQQQKSLVASMRRFSLLKRE 91

  Fly   127 ELHNKNLRLGNQLMTR-FNDF----KANLPAENDYSLEARMKRTLFYGLHQTFINLWHKNELFLQ 186
            ....|.:::..:.:.| .||.    |.:.......|:..|:.::....:.:.|..:     :|:.
Human    92 STITKEIKIQAEYINRSLNDLVKEVKKSEVENGPSSVVTRILKSQHAAMFRHFQQI-----MFIY 151

  Fly   187 N-----YETKVKKNLRLHTKIINSEASEQEIELLIENKTTKLFVDNFLQETEKERQTLREMMDRF 246
            |     .:.|.|..:....::...|.||:::..::.....::|.::.|.|....:..|.|:..|.
Human   152 NDTIAAKQEKCKTFILRQLEVAGKEMSEEDVNDMLHQGKWEVFNESLLTEINITKAQLSEIEQRH 216

  Fly   247 NELRRLEKSIEEVHALFMRIQTLVMEQSEVIQRVEFHAQQATLHVDKGADELDQAEQHQKK 307
            .||..||..|:::..||::|..||.||.|.|..:|........:|:...::...|.:::|:
Human   217 KELVNLENQIKDLRDLFIQISLLVEEQGESINNIEMTVNSTKEYVNNTKEKFGLAVKYKKR 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syx4	NP_525057.2	COG5074	<187..313	CDD:227406	30/126 (24%)
		SNARE_syntaxin1-like	238..298	CDD:277201	19/59 (32%)
STX19	NP_001001850.1	Syntaxin	49..244	CDD:459942	37/199 (19%)
		SNARE	212..278	CDD:473982	19/66 (29%)