Protein Alignment Syx4 and STX12

DIOPT Version :10

• Sequence 1: NP_525057.2
• Gene: Syx4 / 31269
• FlyBaseID: FBgn0024980
• Length: 333
• Species: Drosophila melanogaster
• Sequence 2: NP_803173.1
• Gene: STX12 / 23673
• HGNCID: 11430
• Length: 276
• Species: Homo sapiens
• Alignment Length: 322
• Identity: 67/322 - (20%)
• Similarity: 138/322 - (42%)
• Gaps: 99/322 - (30%)

  Fly    41 GNTGGNNNSYSVVSQNSHSCSNN-NSSTEPKDRSSSKMTQYGSNVDDILNPYTEIRQQLAQIAAN 104
            |.:|.....:|.:.|   :||.| ...::...:..:.|:|.|:..|.     :::::.|.|:.
Human    13 GPSGPQLRDFSSIIQ---TCSGNIQRISQATAQIKNLMSQLGTKQDS-----SKLQENLQQLQ-- 67

  Fly   105 LETMNRMAQTVN------------LRTFNENEMDELHNKNLRLGNQLMTRFNDFKA--------- 148
             .:.|::|:..|            |.| :|.....|..:  ||.|......|:|:|
Human    68 -HSTNQLAKETNELLKELGSLPLPLST-SEQRQQRLQKE--RLMNDFSAALNNFQAVQRRVSEKE 128

  Fly   149 -----------NLPAENDYSLEARMKRTLFYGLHQTFINLWHKNELFLQNYETKVKKNLRLHTKI 202
                       .|.||.    ..|.::.:.:..|:.    |::    :|:.|.:|
Human   129 KESIARARAGSRLSAEE----RQREEQLVSFDSHEE----WNQ----MQSQEDEV---------- 171

  Fly   203 INSEASEQEIELLIENKTTKLFVDNFLQETEKERQTLREMMDRFNELRRLEKSIEEVHALFMRIQ 267
               ..:||::||:                  |||:|         .:|:||..|.:|:.:|..:.
Human   172 ---AITEQDLELI------------------KERET---------AIRQLEADILDVNQIFKDLA 206

  Fly   268 TLVMEQSEVIQRVEFHAQQATLHVDKGADELDQAEQHQKKARKKKIMLIVILAAVLLVLLLV 329
            .::.:|.::|..:|.:.:.:.:||::..::|.:|..:|||:|||..:|:::|:.::|:|.|:
Human   207 MMIHDQGDLIDSIEANVESSEVHVERATEQLQRAAYYQKKSRKKMCILVLVLSVIILILGLI 268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syx4	NP_525057.2	COG5074	<187..313	CDD:227406	29/125 (23%)
		SNARE_syntaxin1-like	238..298	CDD:277201	12/59 (20%)
STX12	NP_803173.1	Syntaxin_2	30..132	CDD:464199	21/112 (19%)
		SNARE_syntaxin12	181..247	CDD:277229	19/92 (21%)