DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syx4 and STX1B

DIOPT Version :9

Sequence 1:	NP_525057.2	Gene:	Syx4 / 31269	FlyBaseID:	FBgn0024980	Length:	333	Species:	Drosophila melanogaster
Sequence 2:	NP_443106.1	Gene:	STX1B / 112755	HGNCID:	18539	Length:	288	Species:	Homo sapiens

Alignment Length:	250	Identity:	59/250 - (23%)
Similarity:	129/250 - (51%)	Gaps:	10/250 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 VDDILNPYTEIRQQLAQIAANLETMNRMAQTV----NLRTFNENEMDELHNKNLRLGNQLMTRFN 144
            :|:......|||..:.:::.::|.:.:....:    |.....:.|:::|.....:..|::.::..
Human    29 MDEFFEQVEEIRGCIEKLSEDVEQVKKQHSAILAAPNPDEKTKQELEDLTADIKKTANKVRSKLK 93

  Fly   145 DFKANLPAE---NDYSLEARMKRTLFYGLHQTFINLWHKNELFLQNYETKVKKNLRLHTKIINSE 206
            ..:.::..|   |..|.:.|:::|....|.:.|:.:..:.......|..:.|..::...:|....
Human    94 AIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMTEYNATQSKYRDRCKDRIQRQLEITGRT 158

  Fly   207 ASEQEIELLIENKTTKLFVDNFLQETEKERQTLREMMDRFNELRRLEKSIEEVHALFMRIQTLVM 271
            .:.:|:|.::|:....:|.|:...:::..:|.|.|:..|.||:.:||.||.|:|.:|:.:..||.
Human   159 TTNEELEDMLESGKLAIFTDDIKMDSQMTKQALNEIETRHNEIIKLETSIRELHDMFVDMAMLVE 223

  Fly   272 EQSEVIQRVEFHAQQATLHVDKGADELDQAEQHQKKARKKKIMLI---VILAAVL 323
            .|.|:|.|:|::.:.:..:|::...:..:|.::|.|||:||||:|   |:|..||
Human   224 SQGEMIDRIEYNVEHSVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVVLGVVL 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syx4	NP_525057.2	Syntaxin	93..273	CDD:279182	38/186 (20%)
Syx4	NP_525057.2	SNARE_syntaxin1-like	238..298	CDD:277201	20/59 (34%)
STX1B	NP_443106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Syntaxin	29..226	CDD:395647	39/196 (20%)
		SNARE	227..278	CDD:399038	17/50 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53912
OrthoDB	1	1.010	-	-		D1033833at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930