Protein Alignment crm and cramp1

DIOPT Version :10

• Sequence 1: NP_477105.2
• Gene: crm / 31268
• FlyBaseID: FBgn0000376
• Length: 982
• Species: Drosophila melanogaster
• Sequence 2: XP_003198126.2
• Gene: cramp1 / 336311
• ZFINID: ZDB-GENE-030131-8255
• Length: 1132
• Species: Danio rerio
• Alignment Length: 1182
• Identity: 288/1182 - (24%)
• Similarity: 444/1182 - (37%)
• Gaps: 353/1182 - (29%)

  Fly     9 PPPPLTQPP-----------------------PPSSSV--SIEEPLPNGKGGG---------AVV 39
            ||.|...|.                       |||..:  ....|..||.||.         :|.
Zfish    85 PPGPQVNPTALSPGLAVPNNQDQHHFLRSSVRPPSKRIRKDASSPALNGHGGAKAKGAEAGPSVC 149

  Fly    40 VNSIAKLPEEELLGSVTMHNCPGTRASARVIQKMKQDQTRPMTPPPSEREPNKKEEKAAQKTPSQ 104
            |.:.|        ||.......||..||                 |..:.|.:|||..:||
Zfish   150 VAAAA--------GSAGGSGAGGTSRSA-----------------PKGQGPAEKEEGGSQK---- 185

  Fly   105 LKTGSGKTTWTNVERNCFFDALNEFGKDFEAVANCINAKLKRRNANSDYSFKTKDQVRQHYYQTH 169
             :......:|:..::|.||:.|.|.||||||:.|.|..|.|::...:. ..|.|:|||..||:|.
Zfish   186 -RVRRQWESWSTEDKNSFFEGLYEHGKDFEAIQNNIALKYKKKGKPAS-MVKNKEQVRHFYYRTW 248

  Fly   170 HKICKYVRF----SEELKKPAQELYTLINYGEMRRKL-QFLTEKHFMKLKQLVYQGQITVRCKGK 229
            |||.|::.|    |..|||.:||||.||.|.|:|:|: ..:.:|:..||.:|:.||..|||.||:
Zfish   249 HKISKHIDFNNVYSRVLKKSSQELYGLICYAELRKKVGGLMDDKNVAKLNELIQQGATTVRSKGR 313

  Fly   230 NIRIKTPSCKALRRLNQLD-----DSLEDIRLPSKVEVLVTPANMEAFGRVQSLAQNPRGRIIVP 289
            |:|||.|.|:||:::...|     :..:.:|||.||.|.:.|.:..::.||||||.|||.|:::.
Zfish   314 NLRIKAPMCRALKKICDPDGVSDEEDQKPVRLPLKVAVELQPRSNHSWARVQSLAHNPRLRMVIE 378

  Fly   290 LHKKLISFIKTFEYKWRSANQRLHEEKSAYFSSSLPSAASNNNNNNNETEPLQPS-VASLDPSMC 353
            ||:|:.:.|:..:.||...:||:  .||.....:|...|.::.:......|.:.| |.:|
Zfish   379 LHRKVSTLIEFLKQKWAVQDQRI--RKSLAEREALDGLAQSSESEELFLFPAESSTVTAL----- 436

  Fly   354 FQPRPGVA--IHRPLLSITAYLSSISICLTAYEE----RMGFKVRSETLGNLAGMSVAANKRLRT 412
                ||||  :|           |.:.|...::|    |.|  :|.....::.|:..|     |.
Zfish   437 ----PGVARVVH-----------SKASCTVHWQESGRGRTG--IRDLPAAHILGIQPA-----RG 479

  Fly   413 ESGSEKRSPETKKPKSSASPPLEKSLDDGPLEGNLMKMENSSGDELGEEIHEFLGDILEAMQHPQ 477
            :||         ||......  .|..|..|:||:    ::||....|          ||...:|.
Zfish   480 KSG---------KPGPVGGD--SKRTDGHPVEGS----DSSSTSAAG----------LETSANPN 519

  Fly   478 AATIPALSATTGDTTTVAVALETSHDPVQQAYPANADLSNA-MATSVLQTSCAAAPAPSTPVTGS 541
            ..|...:|.|.  |:.:.:..|.:.....:..||:...::| .....::|.....||.|   .|.
Zfish   520 VNTTSPVSPTI--TSLLPIGPEGNPAGSAEQEPASQTQTDAGGGDKQIETVTQGDPASS---EGR 579

  Fly   542 LAAPSVARSKRKEAKEAAAAAQARNFKPLLSDDILKRIR-KGWTQANAADITIGDLYVVFGQDSK 605
            ...|..|.....|.....:.||.|..:.:.:....::|| :||:...:.::|:.:||::.|:..|
Zfish   580 TDEPGTAGGVASEKALPQSEAQGRVEEVVGTGRSPQQIREEGWSSQVSENVTLAELYLMLGKPGK 644

  Fly   606 LELEYYW------------------------------------CEVDSSTAMASSILTINTVTPS 634
            |:|||.|                                    |.|.:|...:..  ..::|||.
Zfish   645 LQLEYEWQSKPNPPSVLPNSQNVLRCLLRLVSSEVNPKPTPEVCSVGTSPLKSGQ--EESSVTPP 707

  Fly   635 SSSVATQTGSAASNANQTGASSNCYVS------------ASSNSSTS---STSLP---------Y 675
            ..:.|....|.:....|..|.|...::            ||...|..   .|:||         :
Zfish   708 GRTPAGANRSPSWGRQQHAARSKILLNNPGGRNLPRSLLASGGDSEGFAVPTTLPPNSSRQSRMF 772

  Fly   676 NPN---------DCDSVERVRAVTTSSVSNKLKHL--------LLVANLSERVRKRQCNCGHTCD 723
            :||         ..||:       :|.:.:|.:.:        .||...:...|.......|.|
Zfish   773 SPNKEAELAFRQQLDSI-------SSDIFSKQRKIGRGRPLRKPLVVQRTLLPRTAGDTSPHVC- 829

  Fly   724 RKRDLMTKAQQLAEATATGGVGGMVEGNFR---TPMLPVRRPISNID-------PVRQLSALTRQ 778
                   ....|:.::|||      .|:||   |.:.|.|:|.|...       ||.|||:...
Zfish   830 -------SFSILSNSSATG------TGSFRPIQTRLAPNRQPSSKASSSTGSPAPVTQLSSAID- 880

  Fly   779 KISRQVLVQRRLLPPTSAGDRPYDLLSVRQLHSGLFEPIDRVDGISSAGISTSGSKPDSSMNATT 843
                        |...|||..|..  ..|::.:   ..||:....|...:.::.:.|:...:..
Zfish   881 ------------LAAKSAGIIPGS--PCREVEA---PSIDKAIVESEDAMGSAPAAPEMEPDIL- 927

  Fly   844 ASQDQEPGDQ-----------GALEFLNDEATQVSARDM-----PNLDICVATNRTDVSSSLNEA 892
               ||||.::           |..|.|....:..|..|:     |...:.....:|.:|.|:.|.
Zfish   928 ---DQEPSEESLQNGVSPPSPGGGESLLAPPSVASLLDISLPGPPEESLPSGEPQTQISDSIIEL 989

  Fly   893 A-----QDGSTTQSFFQGSMSPMHL----------------LRDSTSNARWLEDNINDFSLTSLL 936
            |     .|||.        :||..|                :...|.:.:|..::..|.||..||
Zfish   990 AINSHYGDGSL--------LSPPKLNGSDRSKLLPSSCDSWMPSPTHDPQWYPNDSTDSSLGCLL 1046

  Fly   937 GHLDEIDAT-RDILDPSSSMSVI--------------------------------SESSVDFRHK 968
            ..|...|.| |..|.||||.:::                                ||||||:..:
Zfish  1047 SSLASPDKTRRTALPPSSSTALLGPSLLDSNSHDCFQSRGLPDAAEVDTQLACMMSESSVDYIAR 1111

  Fly   969 FQEIAALLQQQE 980
            |.::|..|...|
Zfish  1112 FNDLAQELSVTE 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
crm	NP_477105.2	SANT	111..171	CDD:197842	24/59 (41%)
cramp1	XP_003198126.2	SANT	193..250	CDD:473887	24/57 (42%)