DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2712 and ZNF264

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_003408.1	Gene:	ZNF264 / 9422	HGNCID:	13057	Length:	627	Species:	Homo sapiens

Alignment Length:	337	Identity:	103/337 - (30%)
Similarity:	153/337 - (45%)	Gaps:	57/337 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 CEIVDDPDPEQRRSRLERSEPALQCPICGKQLARKRTFQYHMRLHGQPKIRQEDNDHCIEECLQV 241
            ||...||       .::..|...:|..|||...:|.....|.::|.  .::..:...|.:..::.
Human   188 CESGKDP-------MIQEEENNFKCSECGKVFNKKHLLAGHEKIHS--GVKPYECTECGKTFIKS 243

  Fly   242 EPVLQ---AKAGEDVYEIVE-------KSAQTSATQKTLPSGSRPWKPLNPSLQCKICGKQLSTN 296
            ..:||   ...||..||.:|       ||..|.  .:.:.||.:|:|       |..|||..:..
Human   244 THLLQHHMIHTGERPYECMECGKAFNRKSYLTQ--HQRIHSGEKPYK-------CNECGKAFTHR 299

  Fly   297 NSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYR----------- 350
            ::|..|.:.|.....:|||.||:.|:.|.....|..:|...||..|..|.||::
Human   300 SNFVLHNRRHTGEKSFVCTECGQVFRHRPGFLRHYVVHSGENPYECLECGKVFKHRSYLMWHQQT 364

  Fly   351 -----------------QASSLRTHLLIHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGC 398
                             ::::|..|.:||:|.|||||..|||....:|..|:|...||||||..|
Human   365 HTGEKPYECSECGKVFLESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKRHQRIHTGEKPFVC 429

  Fly   399 DICGRRFRYSSNLIAHKRCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSERPFGCEQCGKSFK 463
            ..||:.|.:.|..|.|||.|:.|||..|..|.| :|.:..:|.||..:|:.|:|:.|.:|||:|.
Human   430 SECGKAFTHCSTFILHKRAHTGEKPFECKECGK-AFSNRKDLIRHFSIHTGEKPYECVECGKAFT 493

  Fly   464 RRISLAIHRQSH 475
            |...|..|::.|
Human   494 RMSGLTRHKRIH 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..362	CDD:275368	6/47 (13%)
		zf-H2C2_2	354..379	CDD:290200	13/24 (54%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		COG5048	378..>463	CDD:227381	36/84 (43%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		C2H2 Zn finger	426..447	CDD:275368	7/20 (35%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
ZNF264	NP_003408.1	KRAB	14..74	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..155
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..194		2/5 (40%)
		COG5048	184..568	CDD:227381	103/337 (31%)
		C2H2 Zn finger	205..225	CDD:275368	6/19 (32%)
		zf-H2C2_2	221..240	CDD:290200	3/20 (15%)
		C2H2 Zn finger	233..253	CDD:275368	3/19 (16%)
		zf-H2C2_2	245..270	CDD:290200	7/24 (29%)
		C2H2 Zn finger	261..281	CDD:275368	4/21 (19%)
		zf-H2C2_2	273..298	CDD:290200	9/33 (27%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		zf-C2H2	343..365	CDD:278523	4/21 (19%)
		C2H2 Zn finger	345..365	CDD:275368	4/19 (21%)
		zf-H2C2_2	357..380	CDD:290200	0/22 (0%)
		C2H2 Zn finger	373..393	CDD:275368	2/19 (11%)
		zf-C2H2	399..421	CDD:278523	9/21 (43%)
		C2H2 Zn finger	401..421	CDD:275368	7/19 (37%)
		zf-H2C2_2	413..438	CDD:290200	12/24 (50%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		zf-H2C2_2	445..466	CDD:290200	11/21 (52%)
		C2H2 Zn finger	457..477	CDD:275368	7/20 (35%)
		zf-H2C2_2	469..494	CDD:290200	11/24 (46%)
		C2H2 Zn finger	485..505	CDD:275368	8/19 (42%)
		zf-H2C2_2	498..520	CDD:290200	3/8 (38%)
		C2H2 Zn finger	513..533	CDD:275368
		zf-H2C2_2	525..550	CDD:290200
		C2H2 Zn finger	541..561	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	605..627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146671
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840