DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2712 and ZNF394

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_115540.2	Gene:	ZNF394 / 84124	HGNCID:	18832	Length:	561	Species:	Homo sapiens

Alignment Length:	555	Identity:	136/555 - (24%)
Similarity:	212/555 - (38%)	Gaps:	148/555 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PMDALCRVCHTASPRCLPLFKPLDDPISGKPATLASILSYCSGLEILEAELF---LPHHI----- 65
            |.:||.|:    ...|....:|             .:||....||:|..|.|   ||..:
Human    78 PEEALSRL----RELCRRWLRP-------------ELLSKEQILELLVLEQFLTILPEELQAWVR 125

  Fly    66 --CP----DCVAKLR---------------------LSLEFKRSVHRMDRILRQSHADFCRSKKI 103
              ||    :.||.:|                     :||.:: ...|:|...|    ||||.
Human   126 EHCPESGEEAVAVVRALQRALDGTSSQGMVTFEDTAVSLTWE-EWERLDPARR----DFCRE--- 182

  Fly   104 SAVNTRARLSTEIPEDFVLVLDDQEVTEYPAETIRDEEQLLVVESDEAESRLEAPIVQEERL-DI 167
               :.:....:.:|......::::|:  .|.:.|        :|..|.:.:|:.....:..| ..
Human   183 ---SAQKDSGSTVPPSLESRVENKEL--IPMQQI--------LEEAEPQGQLQEAFQGKRPLFSK 234

  Fly   168 ALEQHEDDLCEIVDDPDPEQRRSRLERSEPALQCPICGKQLARKRTFQYHMRLHGQPKIRQEDND 232
            ....|||.:.:...||.|    .:||.|..|                      .|...|...:.:
Human   235 CGSTHEDRVEKQSGDPLP----LKLENSPEA----------------------EGLNSISDVNKN 273

  Fly   233 HCIEECLQVEPVLQAKAGED-VYEIVEKSAQTS--ATQKTLPSGSRP------------------ 276
            ..||             ||| ....::.||:.|  ...:.:|...||
Human   274 GSIE-------------GEDSKNNELQNSARCSNLVLCQHIPKAERPTDSEEHGNKCKQSFHMVT 325

  Fly   277 WKPLNPSLQCKICGKQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNR 341
            |..|.|.....  |.....::.|:...||| ...||.|..||:|||.|:....|..:|....|..
Human   326 WHVLKPHKSDS--GDSFHHSSLFETQRQLH-EERPYKCGNCGKSFKQRSDLFRHQRIHTGEKPYG 387

  Fly   342 CPTCFKVYRQASSLRTHLLIHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFR 406
            |..|.|.:.|:::|..|...|:|.||:.|..||:|..|.|...:|..||:.:|...|:.||...
Human   388 CQECGKSFSQSAALTKHQRTHTGEKPYTCLKCGERFRQNSHLNRHQSTHSRDKHFKCEECGETC- 451

  Fly   407 YSSNLIAHKRCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSERPFGCEQCGKSFKRRISLAIH 471
            :.|||..|:|.|..|:|:.|..|:| ||...|:|.:|..:|:.|:|:||..|||.|.:..:|..|
Human   452 HISNLFRHQRLHKGERPYKCEECEK-SFKQRSDLFKHHRIHTGEKPYGCSVCGKRFNQSATLIKH 515

  Fly   472 RQSH---------KAGRQRRRAEHEVGVQLEEQDE 497
            ::.|         :.|.:.|::.|.:..|...|::
Human   516 QRIHTGEKPYKCLECGERFRQSTHLIRHQRIHQNK 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871	22/113 (19%)
		C2H2 Zn finger	286..306	CDD:275368	3/19 (16%)
		C2H2 Zn finger	314..334	CDD:275368	8/19 (42%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		zf-H2C2_2	354..379	CDD:290200	10/24 (42%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		COG5048	378..>463	CDD:227381	33/84 (39%)
		zf-H2C2_2	384..407	CDD:290200	7/22 (32%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..447	CDD:275368	8/20 (40%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
ZNF394	NP_115540.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..61
		SCAN	60..170	CDD:128708	22/109 (20%)
		KRAB_A-box	155..214	CDD:322003	13/79 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..201		1/24 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..285		18/92 (20%)
		C2H2 Zn finger	337..353	CDD:275368	3/15 (20%)
		COG5048	356..>420	CDD:227381	23/63 (37%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		zf-C2H2	414..436	CDD:306579	7/21 (33%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		C2H2 Zn finger	444..463	CDD:275368	8/19 (42%)
		SFP1	<464..543	CDD:227516	25/79 (32%)
		C2H2 Zn finger	471..491	CDD:275368	8/20 (40%)
		C2H2 Zn finger	499..519	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960