DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and ZNF614

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_079316.2	Gene:	ZNF614 / 80110	HGNCID:	24722	Length:	585	Species:	Homo sapiens

Alignment Length:	476	Identity:	119/476 - (25%)
Similarity:	183/476 - (38%)	Gaps:	121/476 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 QSHADFCRSKK-----ISAVNTRARLSTEIPEDFV-----LVLDDQEVT---------------- 130
            |:|..|...:|     :|.:|.:.|.....|.:|:     |:....|.|
Human   125 QNHDTFDLYRKNLKSSLSLINQKRRHGINNPVEFIGGEKTLLHGKHERTHTKTRFSENAKCIHTK 189

  Fly   131 ------------EYPAETIRDEEQLLVVESDEAESRL---EAPIVQE-------ERL--DIALEQ 171
                        |.|...|..|:..|      .:|:|   |...:||       |:|  .:...:
Human   190 FQVFKHQRTQKIEKPHACIECEQTFL------RKSQLIYHENICIQENPGSGQCEKLSRSVLFTK 248

  Fly   172 H-----EDDLCEIVDDPDPEQRRSRLERS----------EPALQCPICGKQLARKRTFQYHMRLH 221
            |     .|.:|    .|:..::.|.::.|          |.:..|..|||....||....|.|.|
Human   249 HLKTNTTDKIC----IPNEYRKGSTVKSSLITHQQTHTEEKSYMCSECGKGFTMKRYLIAHQRTH 309

  Fly   222 GQPKIRQEDNDHCIEEC---------LQV--------EPVLQAKAGEDV----YEIVEKSAQTSA 265
            ...|      .:..:||         |.|        :|.:.::.|:..    |.:|.:...|
Human   310 SGEK------PYVCKECGKGFTVKSNLIVHQRTHTGEKPYICSECGKGFTMKRYLVVHQRTHT-- 366

  Fly   266 TQKTLPSGSRPWKPLNPSLQCKICGKQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGH 330
                   |.:|:       .|..|||..:..::...|.:.|.....|:|:.||:.|..:.....|
Human   367 -------GEKPY-------MCSECGKGFTVKSNLIVHQRSHTGEKSYICSECGKGFTVKRTLVIH 417

  Fly   331 VTLHDRNNPNRCPTCFKVYRQASSLRTHLLIHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKP 395
            ...|.......|..|.|.:....:|..|...|:|.||:||:.|||..:||....:|...|||:.|
Human   418 QRTHTGEKSYICNECGKGFTTKRTLIIHQRTHTGEKPYECNECGKAFSQKICLIQHERCHTGKTP 482

  Fly   396 HGCDICGRRFRYSSNLIAHKRCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSERPFGCEQCGK 460
            ..|..||:.:.:...||.|:|.|:.|||:.|..|.| :|.:.|.||.|...|:.|||:||..|.|
Human   483 FVCTECGKSYSHKYGLITHQRIHTGEKPYECNECGK-AFTTKSVLNVHQRTHTGERPYGCSDCEK 546

  Fly   461 SFKRRISLAIHRQSH--KAGR 479
            :|....:|..|::.|  :.||
Human   547 AFSHLSNLVKHKKMHTREMGR 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871	119/476 (25%)
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		C2H2 Zn finger	342..362	CDD:275368	5/19 (26%)
		zf-H2C2_2	354..379	CDD:290200	11/24 (46%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		COG5048	378..>463	CDD:227381	34/84 (40%)
		zf-H2C2_2	384..407	CDD:290200	8/22 (36%)
		C2H2 Zn finger	398..418	CDD:275368	7/19 (37%)
		C2H2 Zn finger	426..447	CDD:275368	8/20 (40%)
		zf-H2C2_2	439..464	CDD:290200	12/24 (50%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
ZNF614	NP_079316.2	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	<92..350	CDD:227381	46/240 (19%)
		C2H2 Zn finger	180..199	CDD:275368	0/18 (0%)
		C2H2 Zn finger	207..226	CDD:275368	6/24 (25%)
		C2H2 Zn finger	236..253	CDD:275368	3/16 (19%)
		C2H2 Zn finger	289..309	CDD:275368	8/19 (42%)
		zf-H2C2_2	301..325	CDD:290200	6/29 (21%)
		C2H2 Zn finger	317..337	CDD:275368	4/19 (21%)
		zf-H2C2_2	329..353	CDD:290200	4/23 (17%)
		C2H2 Zn finger	345..365	CDD:275368	3/19 (16%)
		zf-H2C2_2	357..381	CDD:290200	9/39 (23%)
		C2H2 Zn finger	373..393	CDD:275368	5/19 (26%)
		COG5048	<383..562	CDD:227381	60/179 (34%)
		C2H2 Zn finger	401..421	CDD:275368	5/19 (26%)
		C2H2 Zn finger	429..449	CDD:275368	5/19 (26%)
		zf-H2C2_2	442..466	CDD:290200	11/23 (48%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	498..522	CDD:290200	12/24 (50%)
		C2H2 Zn finger	513..533	CDD:275368	8/20 (40%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146628
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030