DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and ZNF557

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001037852.1	Gene:	ZNF557 / 79230	HGNCID:	28632	Length:	430	Species:	Homo sapiens

Alignment Length:	414	Identity:	102/414 - (24%)
Similarity:	171/414 - (41%)	Gaps:	85/414 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LSTEIPEDFVLVLDDQEVTEYPAETIRDEEQLLVVESDEAESRLEAPIVQEERLDIALEQHEDDL 176
            ::.|..::...:||..:.|.|....:.:...|..:.:...:.||.:.:.||:::...........
Human    48 VAVEFTQEEWALLDPAQRTLYRDVMLENCRNLASLGNQVDKPRLISQLEQEDKVMTEERGILSGT 112

  Fly   177 CEIVDDP--------------DPEQRRSRLERSEPAL---QCPICGKQLARKRTFQYHMRLHGQP 224
            |..|::|              ..:.|..::||:....   :|..|.|..:.|.:...|.::|
Human   113 CPDVENPFKAKGLTPKLHVFRKEQSRNMKMERNHLGATLNECNQCFKVFSTKSSLTRHRKIH--- 174

  Fly   225 KIRQEDNDHCIEECLQVEPVLQAKAGEDVYEIVE-----KSAQTSATQKTLPSGSRPWKPLNPSL 284
                                    .||..|...|     .|....|..|.:.:|.:|:
Human   175 ------------------------TGERPYGCSECGKSYSSRSYLAVHKRIHNGEKPY------- 208

  Fly   285 QCKICGKQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVY 349
            :|..|||..|:.:....|.::|....||.|:.||::|...:....|:.:|....|.:|..||:.:
Human   209 ECNDCGKTFSSRSYLTVHKRIHNGEKPYECSDCGKTFSNSSYLRPHLRIHTGEKPYKCNQCFREF 273

  Fly   350 R----------------------------QASSLRTHLLIHSGIKPFECSICGKRLTQKSGYKKH 386
            |                            ..|||.:|..||:|..|:||..||:...::|...:|
Human   274 RTQSIFTRHKRVHTGEGHYVCNQCGKAFGTRSSLSSHYSIHTGEYPYECHDCGRTFRRRSNLTQH 338

  Fly   387 MLTHTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSER 451
            :.|||||||:.|:.||:.|..|.:|..|:|.|:.||.:.|..|.| ||...|.:.:||..|:.::
Human   339 IRTHTGEKPYTCNECGKSFTNSFSLTIHRRIHNGEKSYECSDCGK-SFNVLSSVKKHMRTHTGKK 402

  Fly   452 PFGCEQCGKSFKRRISLAIHRQSH 475
            |:.|..|||||.....|::|.:.|
Human   403 PYECNYCGKSFTSNSYLSVHTRMH 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		C2H2 Zn finger	342..362	CDD:275368	8/47 (17%)
		zf-H2C2_2	354..379	CDD:290200	11/24 (46%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
		COG5048	378..>463	CDD:227381	35/84 (42%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..447	CDD:275368	8/20 (40%)
		zf-H2C2_2	439..464	CDD:290200	10/24 (42%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
ZNF557	NP_001037852.1	KRAB	43..100	CDD:214630	10/51 (20%)
		KRAB	43..82	CDD:279668	6/33 (18%)
		COG5048	<137..422	CDD:227381	87/319 (27%)
		C2H2 Zn finger	154..174	CDD:275368	5/19 (26%)
		C2H2 Zn finger	182..202	CDD:275368	4/19 (21%)
		zf-H2C2_2	194..219	CDD:290200	8/31 (26%)
		C2H2 Zn finger	210..230	CDD:275368	6/19 (32%)
		zf-H2C2_2	222..247	CDD:290200	8/24 (33%)
		C2H2 Zn finger	238..258	CDD:275368	5/19 (26%)
		zf-H2C2_2	254..275	CDD:290200	6/20 (30%)
		C2H2 Zn finger	266..286	CDD:275368	4/19 (21%)
		C2H2 Zn finger	294..314	CDD:275368	4/19 (21%)
		zf-C2H2	320..342	CDD:278523	6/21 (29%)
		C2H2 Zn finger	322..342	CDD:275368	5/19 (26%)
		zf-H2C2_2	334..359	CDD:290200	12/24 (50%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		zf-H2C2_2	362..386	CDD:290200	10/24 (42%)
		C2H2 Zn finger	378..398	CDD:275368	8/20 (40%)
		zf-H2C2_2	390..415	CDD:290200	10/24 (42%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146580
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030