DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and ZNF69

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_006722936.1	Gene:	ZNF69 / 7620	HGNCID:	13138	Length:	569	Species:	Homo sapiens

Alignment Length:	333	Identity:	101/333 - (30%)
Similarity:	144/333 - (43%)	Gaps:	64/333 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 RLERSEPALQCPICGKQLARKRTFQYHMRLHGQPKIRQEDNDHCIEECLQVEPVLQA-------- 247
            |:...|...:|..|||..:...|.:.|.|.|...|         ..||.|......:
Human   243 RIHTGEKPYECKQCGKSFSYSATLRIHERTHTGEK---------PYECQQCGKAFHSPRCYRRHE 298

  Fly   248 --KAGEDVYEIVEKSAQTSATQ-----KTLPSGSRPWKPLNPSLQCKICGKQLSTNNSFKYHMQL 305
              ..||..|:..|.....:..|     :...|..:|:       :|..|||.||:..||:.|:::
Human   299 RIHTGEKAYQCKECGKAFTCPQYVRIHERTHSRKKPY-------ECTQCGKALSSLTSFQTHIRM 356

  Fly   306 HGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYRQASSLRTHLLIHSGIKPFEC 370
            |....||.|.|||:.|.:.|:...|...|....|.:|..|.|.:..:||||.|..||:|.||:||
Human   357 HSGERPYECKICGKGFCSANSFQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYEC 421

  Fly   371 SICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAHK------RCHSQEKPHPCPVC 429
            ..|||.....|..:.|..|||||||:.|..||:.||...||.:|:      |.||.|:|:.|.:|
Human   422 KQCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFRSMKNLQSHERTQTHVRIHSGERPYKCKLC 486

  Fly   430 QK---------------------------RSFGSTSELNRHMLVHSSERPFGCEQCGKSFKRRIS 467
            .|                           .:|.|:|....|...|:.|:|:.|:||||:|:....
Human   487 GKGFYCPKSLQRHEKTHTGEKLYECKQCGEAFSSSSSFRYHERTHTGEKPYKCKQCGKAFRAASV 551

  Fly   468 LAIHRQSH 475
            |.:|.::|
Human   552 LRMHGRTH 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	9/19 (47%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..362	CDD:275368	8/19 (42%)
		zf-H2C2_2	354..379	CDD:290200	14/24 (58%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
		COG5048	378..>463	CDD:227381	37/117 (32%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	9/25 (36%)
		C2H2 Zn finger	426..447	CDD:275368	7/47 (15%)
		zf-H2C2_2	439..464	CDD:290200	10/24 (42%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
ZNF69	XP_006722936.1	KRAB	27..>67	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	169..189	CDD:275368
		C2H2 Zn finger	197..217	CDD:275368
		COG5048	222..>540	CDD:227381	92/312 (29%)
		C2H2 Zn finger	225..245	CDD:275368	1/1 (100%)
		zf-H2C2_2	241..262	CDD:290200	6/18 (33%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		zf-H2C2_2	266..290	CDD:290200	7/32 (22%)
		C2H2 Zn finger	281..301	CDD:275368	2/19 (11%)
		zf-H2C2_2	295..318	CDD:290200	4/22 (18%)
		C2H2 Zn finger	309..329	CDD:275368	2/19 (11%)
		C2H2 Zn finger	337..357	CDD:275368	9/19 (47%)
		zf-H2C2_2	349..372	CDD:290200	10/22 (45%)
		C2H2 Zn finger	365..385	CDD:275368	7/19 (37%)
		zf-H2C2_2	377..400	CDD:290200	6/22 (27%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		zf-H2C2_2	405..430	CDD:290200	14/24 (58%)
		C2H2 Zn finger	421..441	CDD:275368	6/19 (32%)
		C2H2 Zn finger	449..468	CDD:275368	8/18 (44%)
		C2H2 Zn finger	483..503	CDD:275368	3/19 (16%)
		zf-H2C2_2	495..520	CDD:290200	1/24 (4%)
		C2H2 Zn finger	511..531	CDD:275368	4/19 (21%)
		zf-H2C2_2	523..546	CDD:290200	9/22 (41%)
		C2H2 Zn finger	539..559	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146622
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940