DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and ZNF35

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_003411.3	Gene:	ZNF35 / 7584	HGNCID:	13099	Length:	527	Species:	Homo sapiens

Alignment Length:	413	Identity:	106/413 - (25%)
Similarity:	171/413 - (41%)	Gaps:	115/413 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 QLLVVESDEAESRLEAPIVQEERLDIALEQHED--DLCE--------------------IVDD-- 182
            ||||.:::..| ..|.|::..||:..|..|..:  :.||                    ||:|
Human   120 QLLVPKTEICE-EAEKPLIISERIQKADPQGPELGEACEKGNMLKRQRIKREKKDFRQVIVNDCH 183

  Fly   183 -PD--PEQRRSRLERS------------EPALQ-------CPICGKQLARKRTFQYHMRLHGQPK 225
             |:  .|:...:.::|            .|..|       |.:|||..::......|.|:|
Human   184 LPESFKEEENQKCKKSGGKYSLNSGAVKNPKTQLGQKPFTCSVCGKGFSQSANLVVHQRIH---- 244

  Fly   226 IRQEDNDHCIEECLQVEPVLQAKAGEDVYEIVE------KSAQTSATQKTLPSGSRPWKPLNPSL 284
                                   .||..:|..|      :||.....|: :.:|.:|:
Human   245 -----------------------TGEKPFECHECGKAFIQSANLVVHQR-IHTGQKPY------- 278

  Fly   285 QCKICGKQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVY 349
            .|..|||..:.:::...|.::|.....:.|..|.::|...:....|..:|.......|..|.|.:
Human   279 VCSKCGKAFTQSSNLTVHQKIHSLEKTFKCNECEKAFSYSSQLARHQKVHITEKCYECNECGKTF 343

  Fly   350 RQASSLRTHLLIHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAH 414
            .::|:|..|..||:|.|||.|:.|||..||.:....|..:||||||:.|..||:.|...|:||.|
Human   344 TRSSNLIVHQRIHTGEKPFACNDCGKAFTQSANLIVHQRSHTGEKPYECKECGKAFSCFSHLIVH 408

  Fly   415 KRCHSQEKPHPCPVCQK---------------------------RSFGSTSELNRHMLVHSSERP 452
            :|.|:.|||:.|..|.|                           ::|..:|.|..|..:|:.|:|
Human   409 QRIHTAEKPYDCSECGKAFSQLSCLIVHQRIHSGDLPYVCNECGKAFTCSSYLLIHQRIHNGEKP 473

  Fly   453 FGCEQCGKSFKRRISLAIHRQSH 475
            :.|.:|||:|::|.||.:|:::|
Human   474 YTCNECGKAFRQRSSLTVHQRTH 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	4/19 (21%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		zf-H2C2_2	354..379	CDD:290200	12/24 (50%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		COG5048	378..>463	CDD:227381	36/111 (32%)
		zf-H2C2_2	384..407	CDD:290200	11/22 (50%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		C2H2 Zn finger	426..447	CDD:275368	7/47 (15%)
		zf-H2C2_2	439..464	CDD:290200	10/24 (42%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
ZNF35	NP_003411.3	Globular domain	9..221		21/101 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..38
		COG5048	<214..369	CDD:227381	42/189 (22%)
		C2H2 Zn finger	224..244	CDD:275368	6/19 (32%)
		C2H2 Zn finger	252..272	CDD:275368	4/20 (20%)
		C2H2 Zn finger	280..300	CDD:275368	5/19 (26%)
		C2H2 Zn finger	308..328	CDD:275368	4/19 (21%)
		C2H2 Zn finger	336..356	CDD:275368	6/19 (32%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		COG5048	372..>449	CDD:227381	25/76 (33%)
		C2H2 Zn finger	392..412	CDD:275368	9/19 (47%)
		C2H2 Zn finger	420..440	CDD:275368	3/19 (16%)
		C2H2 Zn finger	448..468	CDD:275368	4/19 (21%)
		zf-H2C2_2	460..485	CDD:316026	10/24 (42%)
		zf-C2H2	474..496	CDD:306579	9/21 (43%)
		C2H2 Zn finger	476..496	CDD:275368	9/19 (47%)
		zf-H2C2_2	488..513	CDD:316026	4/9 (44%)
		C2H2 Zn finger	504..524	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146727
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030