DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG2712 and ZNF20

DIOPT Version :9

Sequence 1:NP_570028.1 Gene:CG2712 / 31267 FlyBaseID:FBgn0024975 Length:501 Species:Drosophila melanogaster
Sequence 2:NP_066966.2 Gene:ZNF20 / 7568 HGNCID:12992 Length:532 Species:Homo sapiens


Alignment Length:454 Identity:129/454 - (28%)
Similarity:180/454 - (39%) Gaps:97/454 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 CRSKKISAVNT-RARLSTEIPEDFVLVLDDQEVTEYPAETIRDEE------QLLVVESDEAESRL 155
            |.|.....|.| .:.|:|.|..|  ......|..||.....|::|      .|...:|.:.....
Human   105 CESSVCGEVGTGHSSLNTHIRAD--TGHKSSEYQEYGENPYRNKECKKAFSYLDSFQSHDKACTK 167

  Fly   156 EAP--------------IVQEERLDIALEQHEDD----------------LCEIVDDPDPEQRRS 190
            |.|              .:|..|:     .|..|                ||.|         ..
Human   168 EKPYDGKECTETFISHSCIQRHRV-----MHSGDGPYKCKFCGKAFYFLNLCLI---------HE 218

  Fly   191 RLERSEPALQCPICGKQLARKRTFQYHMRLHGQPKIRQEDNDHCIEEC-------LQVEPVLQAK 248
            |:.......:|..|||...|..|...|.|.|     ...:.|.| :||       .::....::.
Human   219 RIHTGVKPYKCKQCGKAFTRSTTLPVHERTH-----TGVNADEC-KECGNAFSFPSEIRRHKRSH 277

  Fly   249 AGEDVYEI-----VEKSAQTSATQKTLPSGSRPWKPLNPSLQCKICGKQLSTNNSFKYHMQLHGT 308
            .||..||.     |..|..:....|...:|.:|:       :||.|||.....:..:.|.:.|..
Human   278 TGEKPYECKQCGKVFISFSSIQYHKMTHTGEKPY-------ECKQCGKAFRCGSHLQKHGRTHTG 335

  Fly   309 ATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYRQASSLRTHLLIHSGIKPFECSIC 373
            ..||.|..||::|:..:....|...|..:.|..|..|.|.:|.||.|:.|...|||.||.||..|
Human   336 EKPYECRQCGKAFRCTSDLQRHEKTHTEDKPYGCKQCGKGFRCASQLQIHERTHSGEKPHECKEC 400

  Fly   374 GKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPHPCPVCQKRSFGSTS 438
            ||.....|..:.|..||||||||.|..||:.|||.|:|..|:|.|:.:||:.|.||.| :|..:|
Human   401 GKVFKYFSSLRIHERTHTGEKPHECKQCGKAFRYFSSLHIHERTHTGDKPYECKVCGK-AFTCSS 464

  Fly   439 ELNRHMLVHSSERPFGCEQCGKSFKRRIS--LAIHRQSH---------KAGRQRRRA----EHE 487
            .:..|...|:.|:|:.|:.|||:|   ||  :..|.::|         :.|:...||    |||
Human   465 SIRYHERTHTGEKPYECKHCGKAF---ISNYIRYHERTHTGEKPYQCKQCGKAFIRASSCREHE 525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2712NP_570028.1 zf-AD 13..92 CDD:214871
C2H2 Zn finger 286..306 CDD:275368 6/19 (32%)
C2H2 Zn finger 314..334 CDD:275368 5/19 (26%)
C2H2 Zn finger 342..362 CDD:275368 8/19 (42%)
zf-H2C2_2 354..379 CDD:290200 12/24 (50%)
C2H2 Zn finger 370..390 CDD:275368 6/19 (32%)
COG5048 378..>463 CDD:227381 37/84 (44%)
zf-H2C2_2 384..407 CDD:290200 13/22 (59%)
C2H2 Zn finger 398..418 CDD:275368 10/19 (53%)
C2H2 Zn finger 426..447 CDD:275368 7/20 (35%)
zf-H2C2_2 439..464 CDD:290200 9/24 (38%)
C2H2 Zn finger 455..475 CDD:275368 8/21 (38%)
ZNF20NP_066966.2 KRAB 7..>47 CDD:214630
KRAB 7..46 CDD:279668
C2H2 Zn finger 108..127 CDD:275368 5/18 (28%)
COG5048 115..525 CDD:227381 124/442 (28%)
C2H2 Zn finger 146..165 CDD:275368 3/18 (17%)
C2H2 Zn finger 173..193 CDD:275368 2/24 (8%)
C2H2 Zn finger 201..221 CDD:275370 4/28 (14%)
zf-H2C2_2 217..238 CDD:290200 5/20 (25%)
C2H2 Zn finger 229..249 CDD:275368 8/19 (42%)
C2H2 Zn finger 257..277 CDD:275368 3/20 (15%)
zf-H2C2_2 271..294 CDD:290200 5/22 (23%)
C2H2 Zn finger 285..305 CDD:275368 3/19 (16%)
zf-H2C2_2 297..322 CDD:290200 8/31 (26%)
C2H2 Zn finger 313..333 CDD:275368 6/19 (32%)
C2H2 Zn finger 341..361 CDD:275368 5/19 (26%)
C2H2 Zn finger 369..389 CDD:275368 8/19 (42%)
zf-H2C2_2 382..406 CDD:290200 12/23 (52%)
C2H2 Zn finger 397..417 CDD:275368 6/19 (32%)
zf-H2C2_2 409..434 CDD:290200 13/24 (54%)
C2H2 Zn finger 425..445 CDD:275368 10/19 (53%)
zf-H2C2_2 441..462 CDD:290200 10/21 (48%)
C2H2 Zn finger 453..473 CDD:275368 7/20 (35%)
zf-H2C2_2 465..490 CDD:290200 9/27 (33%)
C2H2 Zn finger 481..500 CDD:275368 8/21 (38%)
zf-H2C2_2 494..517 CDD:290200 3/22 (14%)
C2H2 Zn finger 508..528 CDD:275368 6/18 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146637
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24381
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.030

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