DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and Zfp248

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_082611.1	Gene:	Zfp248 / 72720	MGIID:	1919970	Length:	576	Species:	Mus musculus

Alignment Length:	301	Identity:	92/301 - (30%)
Similarity:	130/301 - (43%)	Gaps:	26/301 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 QCPICGKQLARKRTFQYHMRLHGQPK-----------------IRQEDNDHCIEECLQVEPVLQA 247
            :|.||.|.......|.:|..|.|...                 :.||.....|.:..:|......
Mouse   268 ECSICRKSFYVDLQFGHHTALSGSSPYERNEYEKLFCDGTAFIVHQEAYTRKIAQEYKVSNRTWG 332

  Fly   248 KAGEDVYEIVE---KSAQTSATQKTLPSGSRPWKPLNP-----SLQCKICGKQLSTNNSFKYHMQ 304
            |.....::|::   |..:....:|.....|.|.:|..|     :.:|..|||.....::...|.:
Mouse   333 KPALFKHQIIQMGGKPYEYYENRKNFSKKSHPTQPRRPHVGEKTFECGECGKMFWEKSNLTQHQR 397

  Fly   305 LHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYRQASSLRTHLLIHSGIKPFE 369
            .|....||.||.||::|..:.....|...|....|..|..|.|.:...|:|..|...|:|.||:|
Mouse   398 THTGEKPYECTECGKAFCQKPHLTNHQRTHTGEKPYECKQCGKTFCVKSNLTEHQRTHTGEKPYE 462

  Fly   370 CSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPHPCPVCQKRSF 434
            |:.|.|....:|....|..|||||||..|..||:.|...||||.|:|.|:.|||:.|..|.| :|
Mouse   463 CNACRKSFCHRSALTVHQRTHTGEKPFICSECGKSFCVKSNLIVHQRTHTGEKPYKCNECGK-TF 526

  Fly   435 GSTSELNRHMLVHSSERPFGCEQCGKSFKRRISLAIHRQSH 475
            ...|.|.:|...|:.|:|:.|..|||:|.:|..|..|.:.|
Mouse   527 CEKSALTKHQRTHTGEKPYECHVCGKTFSQRSVLTKHLRIH 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		zf-H2C2_2	354..379	CDD:290200	10/24 (42%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
		COG5048	378..>463	CDD:227381	37/84 (44%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	10/19 (53%)
		C2H2 Zn finger	426..447	CDD:275368	7/20 (35%)
		zf-H2C2_2	439..464	CDD:290200	10/24 (42%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
Zfp248	NP_082611.1	KRAB	8..68	CDD:214630
		C2H2 Zn finger	379..399	CDD:275368	5/19 (26%)
		COG5048	403..>469	CDD:227381	23/65 (35%)
		C2H2 Zn finger	407..427	CDD:275368	6/19 (32%)
		C2H2 Zn finger	435..455	CDD:275368	6/19 (32%)
		COG5048	459..>520	CDD:227381	29/60 (48%)
		C2H2 Zn finger	463..483	CDD:275368	5/19 (26%)
		C2H2 Zn finger	491..511	CDD:275368	10/19 (53%)
		zf-H2C2_2	503..526	CDD:404364	12/23 (52%)
		C2H2 Zn finger	519..539	CDD:275368	7/20 (35%)
		zf-H2C2_2	531..556	CDD:404364	10/24 (42%)
		C2H2 Zn finger	547..567	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836685
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030