DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and Zfp169

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_011242711.1	Gene:	Zfp169 / 67911	MGIID:	1915161	Length:	732	Species:	Mus musculus

Alignment Length:	520	Identity:	136/520 - (26%)
Similarity:	206/520 - (39%)	Gaps:	126/520 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ASPRCLPLFKPLDDPISGKPATLASILSYCSGLEILEAELFLP--HHICPDCVAKLRLSLEFKRS 82
            |....:.:.|..|:..||  |.|..  ::..||:.: ..||.|  ||:.|||......|.:..:
Mouse   189 APEEAVTVLKGPDESASG--AVLHG--AFPLGLDDV-TNLFSPQKHHVFPDCGGGFCQSSDLMK- 247

  Fly    83 VHRMDRILRQSHADFCR---SKKISAVNTRARLSTEIPEDFVLVLDDQEVTEYPAETIRDE--EQ 142
            :.|||.:.:......|.   ::|.|....:.:.|.|.|.                  :.:|  ..
Mouse   248 LQRMDGVEKPYSCSECGHQFAQKASLTVHQRKHSGEKPH------------------VCEECGRG 294

  Fly   143 LLVVESDEAESRL----EAPIVQEE-------RLDIALEQ--HEDD---LCEIVDDPDPE----- 186
            .:.|.|..:..::    |:|:|..|       ::|:.|.|  |.|.   :|       ||
Mouse   295 FMYVSSLNSHKKIIHSGESPLVCPECGRGFRQKIDLLLHQRTHLDKKPFVC-------PECGRGF 352

  Fly   187 -QRRSRLERS---------------------------------EPALQCPICGKQLARKRTFQYH 217
             ::.|.|:.|                                 |....||.||::..:|.|...|
Mouse   353 CRKASLLQHSWSHSGDNPFICSVCGRGFRLLSRLLTHQVTHSGEKPHVCPDCGQRFGQKGTLMRH 417

  Fly   218 MRLHGQPKIRQEDNDHCIEECLQVEPVLQAKAGEDVYEIVEKSAQTSATQK-TLPSGSRPWKPLN 281
            .:.|                           .||..:  |.:....|.||| .|....|....:.
Mouse   418 QKTH---------------------------TGEKPF--VCRQCGWSFTQKVNLIRHQRIHTEVK 453

  Fly   282 PSLQCKICGKQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCF 346
            |.| |..||:.....:....|.:.|....||||..||..|..:....||..:|....|..||.|.
Mouse   454 PFL-CPECGRAFEFKSLLTRHRKTHMGEKPYVCPQCGRGFSQKFNLIGHQRIHTGELPFLCPECG 517

  Fly   347 KVYRQASSLRTHLLIHSG-IKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSN 410
            :.:.:.|.|..|...|:| .||::|..||:....||...:|...||||||:.|..|||.|....|
Mouse   518 RAFVKQSMLIRHQRTHAGWEKPYQCPECGRTFEFKSLLTRHQKIHTGEKPYVCPQCGRGFSQKFN 582

  Fly   411 LIAHKRCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSERPFGCEQCGKSFKRRISLAIHRQSH 475
            ||.|::.|:.|||:.||.|.:| |.....|.||..:|:.|:||.|.:||::|.:::||..|:::|
Mouse   583 LIGHQKTHTGEKPYACPQCGQR-FRQKFNLARHQRIHTGEKPFLCAECGRAFGKKVSLIRHQRTH 646

Fly 476 475
Mouse 647 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871	21/73 (29%)
		C2H2 Zn finger	286..306	CDD:275368	4/19 (21%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		zf-H2C2_2	354..379	CDD:290200	9/25 (36%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
		COG5048	378..>463	CDD:227381	37/84 (44%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		C2H2 Zn finger	426..447	CDD:275368	8/20 (40%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
Zfp169	XP_011242711.1	KRAB	14..73	CDD:214630
		C2H2 Zn finger	233..252	CDD:275368	5/19 (26%)
		COG5048	256..727	CDD:227381	115/447 (26%)
		C2H2 Zn finger	260..280	CDD:275368	3/19 (16%)
		C2H2 Zn finger	288..309	CDD:275368	3/20 (15%)
		C2H2 Zn finger	317..337	CDD:275368	4/19 (21%)
		C2H2 Zn finger	345..365	CDD:275368	6/26 (23%)
		C2H2 Zn finger	373..393	CDD:275368	0/19 (0%)
		C2H2 Zn finger	401..421	CDD:275368	7/19 (37%)
		C2H2 Zn finger	429..449	CDD:275368	6/19 (32%)
		C2H2 Zn finger	457..477	CDD:275368	4/19 (21%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		C2H2 Zn finger	542..562	CDD:275368	6/19 (32%)
		C2H2 Zn finger	570..590	CDD:275368	9/19 (47%)
		C2H2 Zn finger	598..618	CDD:275368	8/20 (40%)
		C2H2 Zn finger	626..646	CDD:275368	7/19 (37%)
		C2H2 Zn finger	654..674	CDD:275368
		C2H2 Zn finger	682..702	CDD:275368
		C2H2 Zn finger	710..730	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836682
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030