DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and ZNF77

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_067040.1	Gene:	ZNF77 / 58492	HGNCID:	13150	Length:	545	Species:	Homo sapiens

Alignment Length:	285	Identity:	98/285 - (34%)
Similarity:	141/285 - (49%)	Gaps:	30/285 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 RLERSEPALQCPICGKQLARKRTFQYHMRLHGQPKIRQEDNDHCIEECLQVEPVLQAKAGEDVYE 255
            |....|...:|..|||..:...:|:.|:|.|...|..|  ..||            .|| ...|.
Human   288 RTHTGEKPYECKHCGKSFSCYSSFRDHVRTHTGEKPCQ--CKHC------------GKA-FTCYS 337

  Fly   256 IVEKSAQTSATQKTLPSGSRPWKPLNPSLQCKICGKQLSTNNSFKYHMQLHGTATPYVCTICGES 320
            .:.:..:|.       ||.:|:       :||.|||.....:|.:.||::|....||||..||::
Human   338 SLREHGRTH-------SGEKPY-------ECKECGKAFRYPSSLRAHMRMHTGEKPYVCKQCGKA 388

  Fly   321 FKTRNARDGHVTLHDRNNPNRCPTCFKVYRQASSLRTHLLIHSGIKPFECSICGKRLTQKSGYKK 385
            |........||..|....|.:|..|.|.|..:||||.|:..|:|.|||||..|||..:..|..::
Human   389 FGCPTYFRRHVKTHSGVKPYQCKECGKAYSFSSSLRIHVRTHTGEKPFECKHCGKAFSCHSSLRE 453

  Fly   386 HMLTHTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSE 450
            |:.||:||||:.|:.||:.|.::.....|.|.||..||:.|..|.| ::..:|.|..|:..|:.|
Human   454 HVRTHSGEKPYECNQCGKAFSHAQYFQKHVRSHSGVKPYECTECGK-AYSCSSSLRVHVRTHTGE 517

  Fly   451 RPFGCEQCGKSFKRRISLAIHRQSH 475
            ||:.|:||||:|:...||..|.::|
Human   518 RPYECKQCGKTFRYLASLQAHVRTH 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	8/19 (42%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		C2H2 Zn finger	342..362	CDD:275368	9/19 (47%)
		zf-H2C2_2	354..379	CDD:290200	14/24 (58%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
		COG5048	378..>463	CDD:227381	33/84 (39%)
		zf-H2C2_2	384..407	CDD:290200	11/22 (50%)
		C2H2 Zn finger	398..418	CDD:275368	6/19 (32%)
		C2H2 Zn finger	426..447	CDD:275368	6/20 (30%)
		zf-H2C2_2	439..464	CDD:290200	12/24 (50%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
ZNF77	NP_067040.1	KRAB	4..44	CDD:307490
		C2H2 Zn finger	164..184	CDD:275368
		C2H2 Zn finger	214..234	CDD:275368
		COG5048	237..>544	CDD:227381	98/285 (34%)
		C2H2 Zn finger	242..262	CDD:275368
		C2H2 Zn finger	270..290	CDD:275368	1/1 (100%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		C2H2 Zn finger	326..346	CDD:275368	5/32 (16%)
		C2H2 Zn finger	354..374	CDD:275368	8/19 (42%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		C2H2 Zn finger	410..430	CDD:275368	9/19 (47%)
		C2H2 Zn finger	438..458	CDD:275368	6/19 (32%)
		C2H2 Zn finger	466..486	CDD:275368	6/19 (32%)
		C2H2 Zn finger	494..514	CDD:275368	6/20 (30%)
		C2H2 Zn finger	522..542	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146697
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030