DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and ZSCAN2

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_024305746.1	Gene:	ZSCAN2 / 54993	HGNCID:	20994	Length:	645	Species:	Homo sapiens

Alignment Length:	484	Identity:	127/484 - (26%)
Similarity:	195/484 - (40%)	Gaps:	114/484 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 DFCRSKKISAVNTRARLSTEIPEDFVLVLDDQ--EVTEYPAETIRDEEQLLVVESDEAESRLEAP 158
            :.||......|:|:.::.|.:|::....|.:.  |.:|..|..:.|..|.|   .|....|:..|
Human    82 ELCRRWLRPEVHTKEQMLTMLPKEIQAWLQEHRPESSEEAAALVEDLTQTL---QDSGSQRVHQP 143

  Fly   159 I-------VQEERLDIALEQH-------------------EDDLCEIVDD-PDPE---------- 186
            .       |.......|||.|                   |::..:|..: |:.|
Human   144 FSVLTVCKVSSRSARRALELHLNYFEIQSENGENCNQDMFENESRKIFSEMPEGESAQHSDGESD 208

  Fly   187 -QRRSRLER-------------------------------SEPALQCPICGKQLARKRTFQYHMR 219
             :|.:.::|                               .|...:||.|||..:||.....|.|
Human   209 FERDAGIQRLQGHSPGEDHGEVVSQDREVGQLIGLQGTYLGEKPYECPQCGKTFSRKSHLITHER 273

  Fly   220 LH-GQPKIRQEDNDHCIEECLQVEPVLQAKAGEDVYEIVE--KSAQTSA---TQKTLPSGSRPWK 278
            .| |:...:.::......:............||..|:..:  ||...||   |.:.:.:|.:|:
Human   274 THTGEKYYKCDECGKSFSDGSNFSRHQTTHTGEKPYKCRDCGKSFSRSANLITHQRIHTGEKPF- 337

  Fly   279 PLNPSLQCKICGKQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCP 343
                  ||..|||..|.:.:...|.:.|....||.|..||:||..|::.:.|..:|....|..|.
Human   338 ------QCAECGKSFSRSPNLIAHQRTHTGEKPYSCPECGKSFGNRSSLNTHQGIHTGEKPYECK 396

  Fly   344 TCFKVYRQASSLRTHLLIHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYS 408
            .|.:.:...|:|..|..||:|.||::|:.||:|.:|.|....|..|||||||:.|..||:.|..|
Human   397 ECGESFSYNSNLIRHQRIHTGEKPYKCTDCGQRFSQSSALITHRRTHTGEKPYQCSECGKSFSRS 461

  Fly   409 SNLIAHKRCHSQEKPHPCPVCQK---------------------------RSFGSTSELNRHMLV 446
            |||..|:|.|..|||:.|.||.|                           .||..:|.|.:|..:
Human   462 SNLATHRRTHMVEKPYKCGVCGKSFSQSSSLIAHQGMHTGEKPYECLTCGESFSWSSNLLKHQRI 526

  Fly   447 HSSERPFGCEQCGKSFKRRISLAIHRQSH 475
            |:.|:|:.|.:|||.|.:|..|.:|:::|
Human   527 HTGEKPYKCSECGKCFSQRSQLVVHQRTH 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..362	CDD:275368	5/19 (26%)
		zf-H2C2_2	354..379	CDD:290200	11/24 (46%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		COG5048	378..>463	CDD:227381	40/111 (36%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	10/19 (53%)
		C2H2 Zn finger	426..447	CDD:275368	9/47 (19%)
		zf-H2C2_2	439..464	CDD:290200	10/24 (42%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
ZSCAN2	XP_024305746.1	SCAN	70..157	CDD:322011	17/77 (22%)
		COG5048	251..631	CDD:227381	99/312 (32%)
		C2H2 Zn finger	255..275	CDD:275368	9/19 (47%)
		C2H2 Zn finger	283..303	CDD:275368	0/19 (0%)
		C2H2 Zn finger	311..331	CDD:275368	5/19 (26%)
		C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	10/19 (53%)
		C2H2 Zn finger	479..499	CDD:275368	4/19 (21%)
		C2H2 Zn finger	507..527	CDD:275368	5/19 (26%)
		C2H2 Zn finger	535..555	CDD:275368	8/19 (42%)
		C2H2 Zn finger	563..583	CDD:275368
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	2.060