DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and ZNF805

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001018857.2	Gene:	ZNF805 / 390980	HGNCID:	23272	Length:	627	Species:	Homo sapiens

Alignment Length:	366	Identity:	109/366 - (29%)
Similarity:	169/366 - (46%)	Gaps:	62/366 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 SDEAESRLEAPIVQEERLDIALEQHEDDLCEIVDDPDPEQRRSRLERSEPALQCPICGKQLARKR 212
            :|...||    |:| :|:.:..:.|:   |    |.....:...::..|...:|..|.|...:||
Human   164 ADSVCSR----IIQ-DRVSLGDDVHD---C----DSHGSGKNPVIQEEENIFKCNECEKVFNKKR 216

  Fly   213 TFQYHMRLHGQPKIRQEDNDHCIEECLQVEPVLQ---AKAGEDVYEIVE-------KSAQTSATQ 267
            ....|.|:|.  .::..:...|.:...:...:||   ...||..|:.:|       ||..|.  .
Human   217 LLARHERIHS--GVKPYECTECGKTFSKSTYLLQHHMVHTGEKPYKCMECGKAFNRKSHLTQ--H 277

  Fly   268 KTLPSGSRPWKPLNPSLQCKICGKQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVT 332
            :.:.||.:|:|       |..|||..:..::|..|.:.|....|:||..||::|:.|.....|..
Human   278 QRIHSGEKPYK-------CSECGKAFTHRSTFVLHNRSHTGEKPFVCKECGKAFRDRPGFIRHYI 335

  Fly   333 LHDRNNPNRCPTCFKVYR----------------------------QASSLRTHLLIHSGIKPFE 369
            :|...||..|..|.||::                            ::::|..|.:||:|.||||
Human   336 IHSGENPYECFECGKVFKHRSYLMWHQQTHTGEKPYECSECGKAFCESAALIHHYVIHTGEKPFE 400

  Fly   370 CSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPHPCPVCQKRSF 434
            |..|||....:|..|:|...||||||:.|..||:.|.:.|..|.|||.|:.|||..|..|.| :|
Human   401 CLECGKAFNHRSYLKRHQRIHTGEKPYVCSECGKAFTHCSTFILHKRAHTGEKPFECKECGK-AF 464

  Fly   435 GSTSELNRHMLVHSSERPFGCEQCGKSFKRRISLAIHRQSH 475
            .:.::|.||..:|:.|:|:.|.:|||:|.||..|..|::.|
Human   465 SNRADLIRHFSIHTGEKPYECMECGKAFNRRSGLTRHQRIH 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		C2H2 Zn finger	342..362	CDD:275368	6/47 (13%)
		zf-H2C2_2	354..379	CDD:290200	13/24 (54%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		COG5048	378..>463	CDD:227381	36/84 (43%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		C2H2 Zn finger	426..447	CDD:275368	7/20 (35%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
ZNF805	NP_001018857.2	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..95
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..162
		COG5048	192..568	CDD:227381	100/326 (31%)
		C2H2 Zn finger	205..225	CDD:275368	7/19 (37%)
		zf-H2C2_2	218..241	CDD:290200	4/24 (17%)
		C2H2 Zn finger	233..253	CDD:275368	3/19 (16%)
		zf-H2C2_2	245..270	CDD:290200	6/24 (25%)
		C2H2 Zn finger	261..281	CDD:275368	4/21 (19%)
		zf-H2C2_2	273..298	CDD:290200	9/33 (27%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		zf-H2C2_2	305..324	CDD:290200	7/18 (39%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		zf-C2H2	343..365	CDD:278523	4/21 (19%)
		C2H2 Zn finger	345..365	CDD:275368	4/19 (21%)
		zf-H2C2_2	357..380	CDD:290200	0/22 (0%)
		C2H2 Zn finger	373..393	CDD:275368	2/19 (11%)
		zf-C2H2	399..421	CDD:278523	9/21 (43%)
		C2H2 Zn finger	401..421	CDD:275368	7/19 (37%)
		zf-H2C2_2	413..438	CDD:290200	12/24 (50%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		zf-H2C2_2	445..466	CDD:290200	11/21 (52%)
		C2H2 Zn finger	457..477	CDD:275368	7/20 (35%)
		zf-H2C2_2	469..494	CDD:290200	11/24 (46%)
		C2H2 Zn finger	485..505	CDD:275368	9/19 (47%)
		zf-H2C2_2	498..520	CDD:290200	3/8 (38%)
		C2H2 Zn finger	513..533	CDD:275368
		zf-H2C2_2	525..550	CDD:290200
		C2H2 Zn finger	541..561	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146669
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930