DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and Zfp882

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001160117.1	Gene:	Zfp882 / 382019	MGIID:	3642748	Length:	555	Species:	Mus musculus

Alignment Length:	477	Identity:	125/477 - (26%)
Similarity:	188/477 - (39%)	Gaps:	117/477 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 NTRARLSTEIPEDFVLVLDDQEVTEYPA-------------------ETIRDEEQLLVVESDEAE 152
            |.|......:..|:.| .:.||.||.|.                   :|..:|:.....:::::.
Mouse    58 NLRKIPPISVQTDYKL-CESQECTEKPGTCKKCGKFFSSPQSFLEHMKTHNEEKTYKYKQTEDSF 121

  Fly   153 SR------------LEAPIV----QEERLDIA-LEQH-------EDDLCEIVD----DPDPEQRR 189
            ||            .|.|.|    .::.|.:| ::||       |..:|::..    ........
Mouse   122 SRHSFVQGHERMHATEQPCVLKQSGKDSLTLAGIQQHIITHNGDEPYICKVCGKAFYSSSSFLTH 186

  Fly   190 SRLERSEPALQCPICGKQLARKRTFQYHMRLH-GQ------------PKIRQED----------- 230
            .|....|....|..|||........:.|.|.| |:            |.:|:.:
Mouse   187 KRTHTREQLYICKQCGKTFTYSSGLRRHERTHSGEKPYECKQFLKVFPSLRKVESHEQTHNGIKY 251

  Fly   231 ---------NDHCIEECLQ-----VEPVLQAKAGEDV------------------YE--IVEKS- 260
                     :|||..:|.:     .:|.:..:.|:..                  ||  :..|:
Mouse   252 ICNQCGIAFSDHCSLQCHEKIHSLEKPYVYKQCGKTFTCSSALRRHERIHTGVKPYECKVCGKAF 316

  Fly   261 AQTSATQ--KTLPSGSRPWKPLNPSLQCKICGKQLSTNNSFKYHMQLHGTATPYVCTICGESFKT 323
            ...|:.|  :.:.||.:|:       .||:|||..|...|.|.|.::|....||.|..||::|..
Mouse   317 IDCSSLQCHERIHSGEKPY-------VCKLCGKAFSRQGSLKCHERIHSGEKPYACKQCGKAFMH 374

  Fly   324 RNARDGHVTLHDRNNPNRCPTCFKVYRQASSLRTHLLIHSGIKPFECSICGKRLTQKSGYKKHML 388
            .||...|..:|.......|..|.|.:..:|:|:.|..||||:||..|.:|||..|..|....|..
Mouse   375 HNALRYHEQIHRGEKAYGCKQCGKAFVLSSALKKHERIHSGLKPCLCRVCGKAFTFHSSLHCHER 439

  Fly   389 THTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSERPF 453
            |||||||:.|..||:.|.|.|:|..|:..||.|||:.|.:| ..:|...|.|.||..:|..|:|:
Mouse   440 THTGEKPYVCKQCGKAFMYHSSLRCHENIHSAEKPYVCKLC-GTAFTYHSSLQRHERIHRGEKPY 503

  Fly   454 GCEQCGKSFKRRISLAIHRQSH 475
            .|:.|.|:|....||..|.:.|
Mouse   504 VCKFCAKAFTDHSSLRCHERIH 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	9/19 (47%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		zf-H2C2_2	354..379	CDD:290200	12/24 (50%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		COG5048	378..>463	CDD:227381	36/84 (43%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..447	CDD:275368	7/20 (35%)
		zf-H2C2_2	439..464	CDD:290200	10/24 (42%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
Zfp882	NP_001160117.1	KRAB	4..43	CDD:279668
		KRAB	4..>41	CDD:214630
		C2H2 Zn finger	86..106	CDD:275368	0/19 (0%)
		C2H2 Zn finger	114..134	CDD:275368	2/19 (11%)
		COG5048	165..553	CDD:227381	105/369 (28%)
		C2H2 Zn finger	170..190	CDD:275368	2/19 (11%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		C2H2 Zn finger	253..273	CDD:275368	4/19 (21%)
		C2H2 Zn finger	282..301	CDD:275368	1/18 (6%)
		zf-H2C2_2	293..316	CDD:290200	3/22 (14%)
		C2H2 Zn finger	309..329	CDD:275368	3/19 (16%)
		zf-H2C2_2	321..346	CDD:290200	9/31 (29%)
		C2H2 Zn finger	337..357	CDD:275368	9/19 (47%)
		zf-H2C2_2	349..372	CDD:290200	9/22 (41%)
		C2H2 Zn finger	365..385	CDD:275368	7/19 (37%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		C2H2 Zn finger	477..497	CDD:275368	7/20 (35%)
		zf-H2C2_2	489..513	CDD:290200	9/23 (39%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		zf-H2C2_2	517..542	CDD:290200	4/9 (44%)
		C2H2 Zn finger	533..553	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100