DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and Zfp78

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001020334.1	Gene:	Zfp78 / 330463	MGIID:	107783	Length:	512	Species:	Mus musculus

Alignment Length:	299	Identity:	101/299 - (33%)
Similarity:	149/299 - (49%)	Gaps:	30/299 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 RLERSEPALQCPICGKQLARKRTFQYHMRLHGQPKIRQEDNDHCIEEC---------LQVEPVLQ 246
            |:...|...||.:|||...:......|...|...|:.|     | |||         |.|.  .:
Mouse   225 RIHTGEKPYQCTVCGKAFKQSHHLAQHHTTHTHEKLFQ-----C-EECKKAFSQNSYLTVH--RR 281

  Fly   247 AKAGEDVYEIVE--KSAQTS---ATQKTLPSGSRPWKPLNPSLQCKICGKQLSTNNSFKYHMQLH 306
            ...||..|:..|  ||.:..   |....:.:|.:|:|       |:||||..:.:.|...|.::|
Mouse   282 IHTGEKPYKCKECAKSFRQPAHLAQHHRIHTGEKPYK-------CEICGKAFNHSMSLTGHQRVH 339

  Fly   307 GTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYRQASSLRTHLLIHSGIKPFECS 371
            ....||.|..||::|:.......|..:|....|..|..|.|.:|::|.|..|...|:|.|||||.
Mouse   340 SGEKPYKCKDCGKAFRQSIHLVVHSRIHTGEEPYECNECGKTFRESSQLTIHQRNHTGEKPFECK 404

  Fly   372 ICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPHPCPVCQKRSFGS 436
            .|||...:.:...:|...||||||:.|:.||:.|.:::.||.|||.|:.|||:.|..|.| :||.
Mouse   405 QCGKFFNRSAYLARHQKIHTGEKPYECNECGKTFTHAAYLIRHKRVHTGEKPYKCAECGK-AFGD 468

  Fly   437 TSELNRHMLVHSSERPFGCEQCGKSFKRRISLAIHRQSH 475
            .|...:|..:|:.:||:.||:||::|:|:.||..|::.|
Mouse   469 GSSRAQHQRLHTGQRPYVCEKCGRAFRRKSSLNCHQRYH 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	7/19 (37%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		zf-H2C2_2	354..379	CDD:290200	12/24 (50%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
		COG5048	378..>463	CDD:227381	34/84 (40%)
		zf-H2C2_2	384..407	CDD:290200	11/22 (50%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		C2H2 Zn finger	426..447	CDD:275368	7/20 (35%)
		zf-H2C2_2	439..464	CDD:290200	9/24 (38%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
Zfp78	NP_001020334.1	KRAB	14..73	CDD:214630
		COG5048	202..>487	CDD:227381	91/277 (33%)
		C2H2 Zn finger	207..227	CDD:275368	1/1 (100%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		C2H2 Zn finger	263..283	CDD:275368	6/22 (27%)
		C2H2 Zn finger	291..311	CDD:275368	4/19 (21%)
		C2H2 Zn finger	319..339	CDD:275368	7/19 (37%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		C2H2 Zn finger	375..395	CDD:275368	7/19 (37%)
		C2H2 Zn finger	403..423	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..451	CDD:275368	9/19 (47%)
		C2H2 Zn finger	459..479	CDD:275368	7/20 (35%)
		C2H2 Zn finger	487..507	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836706
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930