DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and Gm14325

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001020020.2	Gene:	Gm14325 / 329575	MGIID:	3702875	Length:	498	Species:	Mus musculus

Alignment Length:	314	Identity:	97/314 - (30%)
Similarity:	143/314 - (45%)	Gaps:	44/314 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 QRRSRLERSEPALQCPICGKQLARKRTFQYHMRLHGQPKIRQEDNDHCIEECLQVEPVLQAKAGE 251
            |:..|....|...:|..|||..::....:.|.|.|...|         ..||.|..... |::|:
Mouse   203 QKHKRTHTGEKPYECKQCGKAFSQSSHLRIHKRTHTGEK---------PYECNQCGKAF-ARSGD 257

  Fly   252 DVYEIVEKSAQTSATQKTLP---------------------SGSRPWKPLNPSLQCKICGKQLST 295
                 ::|..:|...:|...                     :|.:|:       :||.|||..:.
Mouse   258 -----LQKHKRTHTGEKPYECKQCGKAFAHSSHLHIHERRHTGDKPY-------ECKQCGKAFAV 310

  Fly   296 NNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYRQASSLRTHLL 360
            ..:.:.|.:.|....||.|..||::|........|...|....|..|..|.|.:.|:..||.|..
Mouse   311 FYTLQMHKRTHTGDKPYECKQCGKAFTVIYTLQMHKQTHTGEKPYECKQCGKTFSQSRHLRIHKR 375

  Fly   361 IHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPHP 425
            .|:|.||:||:.|||...:....::|..|||||||:.|:.||:.|.....|..|||.|:.|||:.
Mouse   376 THTGEKPYECNQCGKAFARSGDQQEHKRTHTGEKPYECNQCGKAFIRRRVLQIHKRTHTGEKPYE 440

  Fly   426 CPVCQKRSFGSTSELNRHMLVHSSERPFGCEQCGKSFKRRISLAIHRQSHKAGR 479
            |..|.| :|.|:|:|.:|...||.|:|:.|:||||:|.:...|.||:|:|...|
Mouse   441 CKQCGK-AFASSSDLQKHKRTHSGEKPYECKQCGKAFAQSSHLRIHKQTHTGER 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		zf-H2C2_2	354..379	CDD:290200	12/24 (50%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
		COG5048	378..>463	CDD:227381	37/84 (44%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..447	CDD:275368	8/20 (40%)
		zf-H2C2_2	439..464	CDD:290200	12/24 (50%)
		C2H2 Zn finger	455..475	CDD:275368	10/19 (53%)
Gm14325	NP_001020020.2	KRAB	5..>45	CDD:214630
		KRAB	5..43	CDD:279668
		COG5048	74..459	CDD:227381	81/278 (29%)
		C2H2 Zn finger	79..97	CDD:275368
		C2H2 Zn finger	105..125	CDD:275368
		zf-H2C2_2	118..142	CDD:290200
		C2H2 Zn finger	133..153	CDD:275368
		C2H2 Zn finger	161..181	CDD:275368
		zf-H2C2_2	173..198	CDD:290200
		C2H2 Zn finger	189..209	CDD:275368	2/5 (40%)
		zf-H2C2_2	201..226	CDD:290200	7/22 (32%)
		C2H2 Zn finger	217..237	CDD:275368	6/19 (32%)
		zf-H2C2_2	229..254	CDD:290200	7/34 (21%)
		C2H2 Zn finger	245..265	CDD:275368	5/25 (20%)
		zf-H2C2_2	257..282	CDD:290200	3/29 (10%)
		C2H2 Zn finger	273..293	CDD:275368	0/19 (0%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	314..337	CDD:290200	7/22 (32%)
		C2H2 Zn finger	329..349	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..366	CDD:290200	6/23 (26%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	369..394	CDD:290200	12/24 (50%)
		C2H2 Zn finger	385..405	CDD:275368	5/19 (26%)
		zf-H2C2_2	399..422	CDD:290200	12/22 (55%)
		C2H2 Zn finger	413..433	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..450	CDD:290200	12/24 (50%)
		C2H2 Zn finger	441..461	CDD:275368	8/20 (40%)
		zf-H2C2_2	453..478	CDD:290200	12/24 (50%)
		C2H2 Zn finger	469..489	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100