DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and Zfp169

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_006253807.1	Gene:	Zfp169 / 306816	RGDID:	1304631	Length:	730	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	135/506 - (26%)
Similarity:	208/506 - (41%)	Gaps:	98/506 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ASPRCLPLFKPLDDPISGKPATLASILSYCSGLEILEAELFLP--HHICPDCVAKLRLSLEFKRS 82
            |....:|:.|..|:..||  |.:..  ::..||..: ..||.|  ||:.|||......|.:..:
  Rat   187 APEEAVPVLKGPDESASG--AVIQG--AFPLGLNDV-TNLFSPQKHHVYPDCGGGFCQSSDLMK- 245

  Fly    83 VHRMDRILRQSHADFCR---SKKISAVNTRARLSTEIP-------EDFVLVLDDQEVTEYPAETI 137
            :.|||...:......|.   ::|.|....:.:.|.|.|       ..|:.|           .::
  Rat   246 LQRMDGGEKPYSCSECGHQFTQKASLTVHQRKHSGEKPHVCGECGRGFMYV-----------SSL 299

  Fly   138 RDEEQLLVVESDEAESRLEAPIVQEE-------RLDIALEQHEDDLCEIVDDPDPEQRRSRLERS 195
            ...::  ::.|.      |.|:|..|       ::|:.|.|                 |:.|::
  Rat   300 NSHKK--IIHSG------ERPLVCPECGRGFRQKIDLLLHQ-----------------RTHLDK- 338

  Fly   196 EPALQCPICGKQLARKRTFQYHMRLHG--QPKI--------------------RQEDNDHCIEEC 238
            :|.: ||.||:...||.:...|...|.  .|.|                    ...:..|...:|
  Rat   339 KPFV-CPECGRGFCRKASLLQHRWSHSGDNPFICSVCGRGFRLLSRLLTHQITHSGEKPHVCPDC 402

  Fly   239 LQ-------VEPVLQAKAGEDVYEIVEKSAQTSATQK-TLPSGSRPWKPLNPSLQCKICGKQLST 295
            .|       :....:...||..|  |.:....|.||| .|....|....:.|.| |..||:....
  Rat   403 GQRFGQKGTLMRHQKTHTGEKPY--VCRQCGWSFTQKVNLIRHQRIHTEVKPFL-CPECGRAFEF 464

  Fly   296 NNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYRQASSLRTHLL 360
            .:....|.:.|....||||..||..|..:....||..:|....|..||.|.:.:.:.::|..|..
  Rat   465 KSLLTRHRKTHTGEKPYVCPQCGRGFSQKFNLIGHQRIHAGELPFLCPECGRAFVKKATLIRHQR 529

  Fly   361 IHSG-IKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPH 424
            .|:| .||::|..||:....||...:|...||||||:.|..|||.|....|||.|::.|:.|||:
  Rat   530 THAGWEKPYQCPECGRTFEFKSLLTRHQKIHTGEKPYVCPQCGRGFSQKFNLIGHQKTHTGEKPY 594

  Fly   425 PCPVCQKRSFGSTSELNRHMLVHSSERPFGCEQCGKSFKRRISLAIHRQSH 475
            .||.|.:| |.....|.||..:|:.|:||.|.:||::|.:::||..|:::|
  Rat   595 ACPQCGQR-FRQKFNLVRHQRIHTGEKPFLCAECGRAFGKKVSLIRHQRTH 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871	21/73 (29%)
		C2H2 Zn finger	286..306	CDD:275368	4/19 (21%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		C2H2 Zn finger	342..362	CDD:275368	5/19 (26%)
		zf-H2C2_2	354..379	CDD:290200	9/25 (36%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
		COG5048	378..>463	CDD:227381	37/84 (44%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		C2H2 Zn finger	426..447	CDD:275368	8/20 (40%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
Zfp169	XP_006253807.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		C2H2 Zn finger	231..250	CDD:275368	5/19 (26%)
		COG5048	254..725	CDD:227381	114/433 (26%)
		C2H2 Zn finger	258..278	CDD:275368	3/19 (16%)
		zf-H2C2_2	270..293	CDD:290200	4/22 (18%)
		C2H2 Zn finger	286..307	CDD:275368	2/33 (6%)
		C2H2 Zn finger	315..335	CDD:275368	5/36 (14%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		C2H2 Zn finger	371..391	CDD:275368	0/19 (0%)
		zf-H2C2_2	384..406	CDD:290200	3/21 (14%)
		C2H2 Zn finger	399..419	CDD:275368	2/19 (11%)
		zf-H2C2_2	412..436	CDD:290200	5/25 (20%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		zf-H2C2_2	439..463	CDD:290200	7/24 (29%)
		C2H2 Zn finger	455..475	CDD:275368	4/19 (21%)
		zf-H2C2_2	468..492	CDD:290200	9/23 (39%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)
		C2H2 Zn finger	511..531	CDD:275368	5/19 (26%)
		zf-C2H2	538..560	CDD:278523	6/21 (29%)
		C2H2 Zn finger	540..560	CDD:275368	6/19 (32%)
		zf-H2C2_2	553..577	CDD:290200	12/23 (52%)
		C2H2 Zn finger	568..588	CDD:275368	9/19 (47%)
		zf-H2C2_2	584..605	CDD:290200	10/21 (48%)
		C2H2 Zn finger	596..616	CDD:275368	8/20 (40%)
		zf-H2C2_2	608..631	CDD:290200	10/22 (45%)
		C2H2 Zn finger	624..644	CDD:275368	7/19 (37%)
		zf-H2C2_2	636..660	CDD:290200	4/9 (44%)
		C2H2 Zn finger	652..672	CDD:275368
		zf-H2C2_2	667..689	CDD:290200
		C2H2 Zn finger	680..700	CDD:275368
		zf-H2C2_2	696..715	CDD:290200
		C2H2 Zn finger	708..728	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340380
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030