DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and ZNF620

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	XP_016861553.1	Gene:	ZNF620 / 253639	HGNCID:	28742	Length:	467	Species:	Homo sapiens

Alignment Length:	233	Identity:	78/233 - (33%)
Similarity:	119/233 - (51%)	Gaps:	12/233 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 QAKAGEDVYEIVEKSAQTS---ATQKTLPSGSRPWKPLNPSLQCKICGKQLSTNNSFKYHMQLHG 307
            :.|.||. :|.:.|:...|   .|.:|.|||       ..|.:|..||:.......|..|.:.|.
Human   208 EVKNGEK-FEKLGKNISVSTQLTTNQTNPSG-------QISYECGQCGRYFIQMADFHRHEKCHT 264

  Fly   308 TATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYRQASSLRTHLLIHSGIKPFECSI 372
            ....:.|..||:.|:..:....|..:|....|.:|..|.|.....::|..|..||:|.||:||..
Human   265 GEKSFECKECGKYFRYNSLLIRHQIIHTGKKPFKCKECGKGLSSDTALIQHQRIHTGEKPYECKE 329

  Fly   373 CGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPHPCPVCQKRSFGST 437
            |||..:..|.:.:|...|||||.:.|:.|.:.|..||:...|:|.|:.|||:.|..|.|| ..|.
Human   330 CGKAFSSSSVFLQHQRFHTGEKLYECNECWKTFSCSSSFTVHQRMHTGEKPYECKECGKR-LSSN 393

  Fly   438 SELNRHMLVHSSERPFGCEQCGKSFKRRISLAIHRQSH 475
            :.|.:|..:|:.|:||.|::|||:|.::|:|..|::.|
Human   394 TALTQHQRIHTGEKPFECKECGKAFNQKITLIQHQRVH 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		C2H2 Zn finger	342..362	CDD:275368	5/19 (26%)
		zf-H2C2_2	354..379	CDD:290200	12/24 (50%)
		C2H2 Zn finger	370..390	CDD:275368	6/19 (32%)
		COG5048	378..>463	CDD:227381	33/84 (39%)
		zf-H2C2_2	384..407	CDD:290200	9/22 (41%)
		C2H2 Zn finger	398..418	CDD:275368	7/19 (37%)
		C2H2 Zn finger	426..447	CDD:275368	7/20 (35%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
ZNF620	XP_016861553.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146646
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930