DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and Zfp180

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_653358.2	Gene:	Zfp180 / 246279	RGDID:	631380	Length:	727	Species:	Rattus norvegicus

Alignment Length:	450	Identity:	117/450 - (26%)
Similarity:	183/450 - (40%)	Gaps:	94/450 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 CVAKLRLS---LEFKRSVHRMDRILRQSHADFCRSKKISAVNTRARL-----STEIPEDFVLVLD 125
            |::..|.|   :..:...|:....:::.|.|...|.:  .:|..|..     |.::|:..
  Rat   238 CLSTSRPSFPMIPLRNHFHKQASHVKKLHGDVANSHQ--QINNNADFFEDDKSGKVPQSL----- 295

  Fly   126 DQEVTEYPAETIRDEEQLLVVESD--------------------EAES--------RLEAPIVQE 162
                  :|.:.||..:.....|.:                    |.:|        .|...||..
  Rat   296 ------HPTQCIRTPKGKKACEFNGRVQPFGQGVPLNLNQKVHLEGKSFGFKGRGQVLNRNIVLN 354

  Fly   163 ERLDIALEQHEDDLCEIVDDPD-PEQRRSRLERSEPALQCPICGKQLARKRTFQYHMRLHGQPKI 226
            |:..:.:::.:....:....|. |:..|:..|  |...:|..|||..:.......|.|.|
  Rat   355 EQQKLLIKEGQYKCSKTAPSPSLPQNLRNYSE--EKRFECKYCGKSFSWSSHLIAHQRTH----- 412

  Fly   227 RQEDNDHCIEECLQVEPVLQAKAGEDVY------EIVEKSAQTSATQKTLPSGSRPWKPLNPSLQ 285
                                  .||..|      :...:|:...:.|: :.:|.:|::
  Rat   413 ----------------------TGEKPYKCNLCGKFFTRSSHVVSHQR-IHTGEKPYR------- 447

  Fly   286 CKICGKQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYR 350
            |.:|||..:.......|.:.|....||.|..||:||:.......|...|....|..|..|.|.:.
  Rat   448 CNLCGKSFTQRYVLVVHQRTHTGERPYECNQCGKSFRQSYKLIAHQRTHTGEKPYECTQCGKSFI 512

  Fly   351 QASSLRTHLLIHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAHK 415
            |:..|..|..||||.||:|||.|||..:|......|..|||||||..|:.||:.|.:||.|::|:
  Rat   513 QSYKLIAHQKIHSGEKPYECSHCGKSFSQSYKLVAHQRTHTGEKPFECNYCGKSFSWSSQLVSHQ 577

  Fly   416 RCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSERPFGCEQCGKSFKRRISLAIHRQSH 475
            |.|:.|||:.|..|.| ||..:|.|..|...|:.|:|:.|:||||||.:...|.:|:::|
  Rat   578 RTHTGEKPYECNECGK-SFNRSSHLVMHQRTHTGEKPYQCKQCGKSFSQSYVLVVHQRTH 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871	4/25 (16%)
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		zf-H2C2_2	354..379	CDD:290200	14/24 (58%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		COG5048	378..>463	CDD:227381	39/84 (46%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		C2H2 Zn finger	426..447	CDD:275368	8/20 (40%)
		zf-H2C2_2	439..464	CDD:290200	12/24 (50%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
Zfp180	NP_653358.2	C2H2 Zn finger	368..384	CDD:275368	3/15 (20%)
		COG5048	369..723	CDD:227381	95/305 (31%)
		zf-C2H2	390..412	CDD:278523	6/21 (29%)
		C2H2 Zn finger	392..412	CDD:275368	6/19 (32%)
		zf-H2C2_2	404..429	CDD:290200	6/51 (12%)
		C2H2 Zn finger	420..440	CDD:275368	2/20 (10%)
		zf-H2C2_2	432..457	CDD:290200	7/32 (22%)
		C2H2 Zn finger	448..468	CDD:275368	5/19 (26%)
		zf-H2C2_2	461..485	CDD:290200	9/23 (39%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		zf-H2C2_2	492..513	CDD:290200	6/20 (30%)
		C2H2 Zn finger	504..524	CDD:275368	6/19 (32%)
		zf-H2C2_2	520..541	CDD:290200	13/20 (65%)
		C2H2 Zn finger	532..552	CDD:275368	7/19 (37%)
		zf-H2C2_2	545..568	CDD:290200	11/22 (50%)
		C2H2 Zn finger	560..580	CDD:275368	9/19 (47%)
		zf-H2C2_2	573..597	CDD:290200	12/24 (50%)
		C2H2 Zn finger	588..608	CDD:275368	8/20 (40%)
		zf-H2C2_2	600..625	CDD:290200	12/24 (50%)
		C2H2 Zn finger	616..636	CDD:275368	9/19 (47%)
		zf-H2C2_2	629..653	CDD:290200	2/7 (29%)
		C2H2 Zn finger	644..664	CDD:275368
		zf-H2C2_2	659..680	CDD:290200
		C2H2 Zn finger	672..692	CDD:275368
		zf-H2C2_2	685..707	CDD:290200
		C2H2 Zn finger	700..720	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100