DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2712 and A430033K04Rik

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_898846.2	Gene:	A430033K04Rik / 243308	MGIID:	3583896	Length:	680	Species:	Mus musculus

Alignment Length:	612	Identity:	131/612 - (21%)
Similarity:	228/612 - (37%)	Gaps:	172/612 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ASPRCLPLFKPLDDPI-SGKPATLASILSYCSGLEIL--------EAELFLPHHICPDCVAKLRL 75
            |:.:|||..:....|: .|:    .|...|...::|:        :.|:...:::..:|::.:.|
Mouse    80 ATEQCLPGVRKWSAPVEKGQ----QSQEKYLRQVKIIKKNTPDEDKVEVENTYNVDSNCISNMTL 140

  Fly    76 SLE------FKRSVHRM----------DRILRQSHADFCRSKKI--------------------- 103
            ..|      |:..|:.:          :|...:...|..|::::
Mouse   141 KNEVCSRVFFQELVNPLLDVPLPTEAGERQSTEVPHDLNRTQEVLSYPKHFTHHSKDQYSQCCFQ 205

  Fly   104 -----SAVNTRARLSTE----------------------IPEDFVLVLDDQEV------TEYPAE 135
                 .|.:|:|.|:.|                      ||..::..|..|.:      ..:|.:
Mouse   206 YFGPDEAFHTKAILTPEMFYVQETSRTCNNYDKSFDEVTIPAQYMTQLRKQTLGWNICHKIFPNK 270

  Fly   136 T-IRDEEQLLVVESDEAESRLEAPIV---------QEERLDIALEQHEDDLCEIVDDPDPEQRRS 190
            | :.:.:.:...|:|: :...|.||:         ||....|..:.|::::.....|.:.:....
Mouse   271 TELSNHDAMHTGENDD-KCDYEKPIINKSLYLTKHQEAHAGIEPQAHKENIKFFCLDAELQTVDP 334

  Fly   191 RLERSEPALQCPICGKQLARKRTFQYHMRLHGQPKIRQEDNDHCIEECLQV---------EPVL- 245
            .|...:...:|.:.||      ||::      ||:...:...|..|...|.         ||.|
Mouse   335 ELHGEKQVYECKVSGK------TFRH------QPEHISQQRPHACERACQAKEHGEAGCDEPALT 387

  Fly   246 -------QAKAGE--------------DVYEIVEKSAQTSATQKTL--------PSGSRPWKPLN 281
                   :.||.|              ..|:......|.|..::.:        |:......|..
Mouse   388 QHQRLCTEEKACEGKACSKAFHHKSLLPQYQSARADEQQSDCKELMKIYFYVSSPTQHHGPPPPE 452

  Fly   282 PSLQCKICGKQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCF 346
            ...:|..|.|..|..:..:.|.::|....|:.|..|.::|..::....|..:|....|..|..|.
Mouse   453 KPFRCNDCLKTFSHKSQLERHQRMHTGEKPHECKECRKAFCHKSHLIRHQGIHAPEKPYECNECK 517

  Fly   347 KVYRQASSLRTHLLIHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNL 411
            |.:...|.|..|...|:|.|||||..|.|..::.|...:|...|||||||.|..||..|...|:|
Mouse   518 KSFYLRSQLTLHERTHTGEKPFECKECRKAFSRNSHLTQHQKIHTGEKPHKCKECGNAFARKSHL 582

  Fly   412 IAHKRCHSQEKPHPCPVCQK---------------------------RSFGSTSELNRHMLVHSS 449
            |.|::.|:.|:|:.|..|:|                           ::|...:.|.||.::|.|
Mouse   583 IQHQKTHTGERPYECKECRKAFSRKSQLMQHETTHTGERAYECKECRKTFYLKAYLTRHQVIHQS 647

  Fly   450 ERPFGCEQCGKSFKRRISLAIHRQSHK 476
            |:||.|::|||:|.|:..|..|::.||
Mouse   648 EKPFECKKCGKAFSRKSYLTRHQKIHK 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871	16/96 (17%)
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	4/19 (21%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		zf-H2C2_2	354..379	CDD:290200	11/24 (46%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
		COG5048	378..>463	CDD:227381	36/111 (32%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..447	CDD:275368	7/47 (15%)
		zf-H2C2_2	439..464	CDD:290200	13/24 (54%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
A430033K04Rik	NP_898846.2	KRAB	16..75	CDD:214630
		KRAB	16..55	CDD:279668
		COG5048	261..670	CDD:227381	101/421 (24%)
		C2H2 Zn finger	429..449	CDD:275370	1/19 (5%)
		zf-C2H2	455..477	CDD:278523	5/21 (24%)
		C2H2 Zn finger	457..477	CDD:275368	5/19 (26%)
		zf-H2C2_2	470..492	CDD:290200	5/21 (24%)
		C2H2 Zn finger	485..505	CDD:275368	4/19 (21%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..550	CDD:290200	11/23 (48%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		zf-H2C2_2	553..578	CDD:290200	12/24 (50%)
		C2H2 Zn finger	569..589	CDD:275368	8/19 (42%)
		zf-H2C2_2	581..606	CDD:290200	9/24 (38%)
		C2H2 Zn finger	597..617	CDD:275368	3/19 (16%)
		C2H2 Zn finger	625..645	CDD:275368	4/19 (21%)
		zf-H2C2_2	637..662	CDD:290200	13/24 (54%)
		zf-C2H2	651..673	CDD:278523	9/21 (43%)
		C2H2 Zn finger	653..673	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100