DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2712 and Zfp37

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001277279.1	Gene:	Zfp37 / 22696	MGIID:	99181	Length:	594	Species:	Mus musculus

Alignment Length:	573	Identity:	146/573 - (25%)
Similarity:	223/573 - (38%)	Gaps:	146/573 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DDPISGK-----PATLASIL-SYCSGLEILEAELFLPHHICPDCVAKLRLSLEFKRSVHRMDR-- 88
            ::|.|||     |::|..|. ...:|..                 |||:...|     ||.::
Mouse    58 EEPSSGKGKKASPSSLKKIARPKTAGTS-----------------AKLQQDDE-----HREEKQK 100

  Fly    89 ---------ILRQSHADFCRSKKISAVNTRARLSTEIPEDFVLVL---------DDQEVTEYPAE 135
                     .||:..::..:|.:...:..::..|...|.:..|:.         .:.:..:...:
Mouse   101 SQSKLTKEVTLRKKSSNSKKSSEYGLLENKSLHSKHTPSEKKLLKSSSRGKNSNQNSDSLKKKPD 165

  Fly   136 TIRDEEQLLV-----VESDEAESRLEAPIVQEERL-DIALEQHEDDLCEIV---------DD--P 183
            |..|..:.|.     |..||..:|.:...:...:| |...:......||.|         :|  .
Mouse   166 TANDHRKSLSHSASDVNKDEIPTRKKCDKLPNNKLSDKGDKNQTSKKCEKVCRHSASHTKEDKIQ 230

  Fly   184 DPEQRRSRLER-SEP--------ALQCPICGKQLARKRTFQYHMRLHGQPK--------IRQEDN 231
            ..|:|:|.... |:|        ..:|..|||.|:.|:....|.|.|...|        |.....
Mouse   231 TGEKRKSHCRTPSKPEKAPGSGKPYECNHCGKVLSHKQGLLDHQRTHTGEKPYECNECGIAFSQK 295

  Fly   232 DHCIEECLQVEPVLQAKAGEDVYEIVE-------KSAQTSATQKTLPSGSRPWKPLNPSLQCKIC 289
            .|.:..       .:...||..||..:       |.|.|...:  :.:|.:|:|       |..|
Mouse   296 SHLVVH-------QRTHTGEKPYECEQCGKAHGHKHALTDHLR--IHTGEKPYK-------CNEC 344

  Fly   290 GKQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYRQASS 354
            ||....:::...|::.|....||.|..||:||:..::...||..|....|..|..|.|.::..||
Mouse   345 GKTFRHSSNLMQHLRSHTGEKPYECKECGKSFRYNSSLTEHVRTHTGEIPYECNECGKAFKYGSS 409

  Fly   355 LRTHLLIHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSN--------- 410
            |..|:.||:|.|||||:.|||..::||....|..|||.|||:.||.||:.|.:||:
Mouse   410 LTKHMRIHTGEKPFECNECGKTFSKKSHLVIHQRTHTKEKPYKCDECGKAFGHSSSLTYHMRTHT 474

  Fly   411 -------------------LIAHKRCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSERPFGCE 456
                               |..|:|.|:.|||:.|..|.| :|...|.|..|...|:.|:||.|.
Mouse   475 GDCPFECNQCGKAFKQIEGLTQHQRVHTGEKPYECVECGK-AFSQKSHLIVHQRTHTGEKPFECY 538

  Fly   457 QCGKSFKRRISLAIHRQSH------------KAGRQRRRAEHEVGVQLEEQDE 497
            :|||:|..:..|.||::||            ||.:|.......:.:..|||.|
Mouse   539 ECGKAFNAKSQLVIHQRSHTGEKPYECIECGKAFKQNASLTKHMKIHSEEQSE 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871	15/76 (20%)
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		zf-H2C2_2	354..379	CDD:290200	14/24 (58%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		COG5048	378..>463	CDD:227381	38/112 (34%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	10/47 (21%)
		C2H2 Zn finger	426..447	CDD:275368	7/20 (35%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
Zfp37	NP_001277279.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..253		38/216 (18%)
		KRAB	15..62	CDD:214630	1/3 (33%)
		KRAB_A-box	<15..42	CDD:143639
		COG5048	124..486	CDD:227381	94/377 (25%)
		C2H2 Zn finger	257..277	CDD:275368	8/19 (42%)
		zf-H2C2_2	270..294	CDD:290200	5/23 (22%)
		C2H2 Zn finger	285..305	CDD:275368	2/26 (8%)
		zf-H2C2_2	297..319	CDD:290200	5/28 (18%)
		C2H2 Zn finger	313..333	CDD:275368	3/21 (14%)
		zf-H2C2_2	325..350	CDD:290200	9/33 (27%)
		C2H2 Zn finger	341..361	CDD:275368	5/19 (26%)
		zf-H2C2_2	353..378	CDD:290200	9/24 (38%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		zf-H2C2_2	381..406	CDD:290200	7/24 (29%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-H2C2_2	409..433	CDD:290200	14/23 (61%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..460	CDD:290200	11/22 (50%)
		zf-C2H2	451..473	CDD:278523	7/21 (33%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	0/24 (0%)
		C2H2 Zn finger	481..501	CDD:275368	3/19 (16%)
		zf-H2C2_2	494..518	CDD:290200	11/24 (46%)
		C2H2 Zn finger	509..529	CDD:275368	7/20 (35%)
		zf-H2C2_2	521..545	CDD:290200	10/23 (43%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		zf-H2C2_2	550..574	CDD:290200	7/23 (30%)
		C2H2 Zn finger	565..585	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836712
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030