DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and ZNF25

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001316576.1	Gene:	ZNF25 / 219749	HGNCID:	13043	Length:	460	Species:	Homo sapiens

Alignment Length:	429	Identity:	119/429 - (27%)
Similarity:	173/429 - (40%)	Gaps:	106/429 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 TIRDEEQLLVVESDEAESRLEAPIVQEERLDIALEQHE--------------------------- 173
            |::|    ::||..:.|.:|..|..:....|:.||.:.
Human    13 TLKD----VIVEFTKEEWKLLTPAQRTLYKDVMLENYSHLVSVGYHVNKPNAVFKLKQGKEPWIL 73

  Fly   174 ----------DDLCEIVDDPDPEQ-------------RRSRLERSEPALQCPICGKQLARKRTFQ 215
                      :||..|.|.....|             :..:...:|.|.:|..|||...:|....
Human    74 EVEFPHRGFPEDLWSIHDLEARYQESQAGNSRNGELTKHQKTHTTEKACECKECGKFFCQKSALI 138

  Fly   216 YHMRLHGQ----------------------PKIRQEDNDHCIEECLQV-------EPVLQAKAGE 251
            .|...|.:                      .||...|..:..:||.::       ...|:..|||
Human   139 VHQHTHSKGKSYDCDKCGKSFSKNEDLIRHQKIHTRDKTYECKECKKIFYHLSSLSRHLRTHAGE 203

  Fly   252 DVYEI--VEKS----AQTSATQKTLPSGSRPWKPLNPSLQCKICGKQLSTNNSFKYHMQLHGTAT 310
            ..||.  .|||    ...:..||| .:|.:|:       :|..|||..........|.:.|....
Human   204 KPYECNQCEKSFYQKPHLTEHQKT-HTGEKPF-------ECTECGKFFYVKAYLMVHQKTHTGEK 260

  Fly   311 PYVCTICGESFKTRNARDGHVTLHDR----NNPNRCPTCFKVYRQASSLRTHLLIHSGIKPFECS 371
            ||.|..||::|..::    |:|:|.|    ..|.:|..|.|.:.:.|.|:||...|:|.||:||.
Human   261 PYECKECGKAFSQKS----HLTVHQRMHTGEKPYKCKECGKFFSRNSHLKTHQRSHTGEKPYECK 321

  Fly   372 ICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPHPCPVCQKRSFGS 436
            .|.|...|||....|..|||||||..|:.||:.|.|.|:|..|:|.|:.|||:.|..|.| ||..
Human   322 ECRKCFYQKSALTVHQRTHTGEKPFECNKCGKTFYYKSDLTKHQRKHTGEKPYECTECGK-SFAV 385

  Fly   437 TSELNRHMLVHSSERPFGCEQCGKSFKRRISLAIHRQSH 475
            .|.|..|...|:.|:|:.|::|||||.::....||::.|
Human   386 NSVLRLHQRTHTGEKPYACKECGKSFSQKSHFIIHQRKH 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		zf-H2C2_2	354..379	CDD:290200	11/24 (46%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		COG5048	378..>463	CDD:227381	40/84 (48%)
		zf-H2C2_2	384..407	CDD:290200	12/22 (55%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		C2H2 Zn finger	426..447	CDD:275368	8/20 (40%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
ZNF25	NP_001316576.1	KRAB	12..72	CDD:214630	10/62 (16%)
		KRAB	12..51	CDD:279668	10/41 (24%)
		C2H2 Zn finger	124..144	CDD:275368	6/19 (32%)
		COG5048	148..457	CDD:227381	95/290 (33%)
		C2H2 Zn finger	152..172	CDD:275368	1/19 (5%)
		C2H2 Zn finger	180..200	CDD:275368	3/19 (16%)
		zf-H2C2_2	192..215	CDD:290200	8/22 (36%)
		C2H2 Zn finger	208..228	CDD:275368	6/20 (30%)
		zf-H2C2_2	220..243	CDD:290200	9/30 (30%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		zf-H2C2_2	248..273	CDD:290200	8/24 (33%)
		C2H2 Zn finger	264..284	CDD:275368	8/23 (35%)
		zf-H2C2_2	276..301	CDD:290200	8/24 (33%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		zf-H2C2_2	304..327	CDD:290200	11/22 (50%)
		C2H2 Zn finger	320..340	CDD:275368	7/19 (37%)
		zf-H2C2_2	332..357	CDD:290200	12/24 (50%)
		C2H2 Zn finger	348..368	CDD:275368	9/19 (47%)
		zf-H2C2_2	360..384	CDD:290200	11/24 (46%)
		C2H2 Zn finger	376..396	CDD:275368	8/20 (40%)
		zf-H2C2_2	389..413	CDD:290200	11/23 (48%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		C2H2 Zn finger	432..452	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146763
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030