DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and ZNF846

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001071092.1	Gene:	ZNF846 / 162993	HGNCID:	27260	Length:	533	Species:	Homo sapiens

Alignment Length:	341	Identity:	100/341 - (29%)
Similarity:	147/341 - (43%)	Gaps:	72/341 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 RRSRLERSEPALQCPICGKQLARKRTFQYHMRLHGQPKIRQEDNDHCIEECLQVEPVLQAKA--- 249
            |:::....|...:|..|.:....:.:.:.|:|.|      ..|..:..:||        .||
Human   187 RQNKTHTQEKLCECKDCWRTFLNQSSLKLHIRSH------NGDKHYVCKEC--------GKAFSN 237

  Fly   250 ------------GEDVYEIVEKSAQTSATQKT-------LPSGSRPWKPLNPSLQCKICGKQLST 295
                        ||..|  |.|....:.||.|       ..||.:|:|       ||.|||..:.
Human   238 SSHLIGHGRIHSGEKPY--VCKECGKAFTQSTGLKLHIRTHSGEKPYK-------CKECGKAFTH 293

  Fly   296 NNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYRQASSLRTHLL 360
            ::....|.::|....||||..||::|........|:.:|....|..|..|.|.:..:|.|..|:.
Human   294 SSYLTDHTRIHSGKKPYVCMECGKAFTRSTGLILHMRIHTGEKPYECKECGKAFIHSSYLTKHVR 358

  Fly   361 IHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIAHKRCHSQEKPHP 425
            ||||.|.:.|..|||..|:.||...||.|||||||:.|..||:.|..||.|..|.|.|:.|||:.
Human   359 IHSGEKLYLCKACGKAFTRSSGLVLHMRTHTGEKPYECKECGKAFNNSSMLSQHVRIHTGEKPYE 423

  Fly   426 CPVCQK---------------------------RSFGSTSELNRHMLVHSSERPFGCEQCGKSFK 463
            |..|.|                           ::|..::.||.||..|:.|:|:.|::|||:|:
Human   424 CKECGKAFTQSSGLSTHLRTHTGEKACECKECGKAFARSTNLNMHMRTHTGEKPYACKECGKAFR 488

  Fly   464 RRISLAIHRQSHKAGR 479
            ....|.:|.::|...:
Human   489 YSTYLNVHTRTHTGAK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		zf-H2C2_2	354..379	CDD:290200	11/24 (46%)
		C2H2 Zn finger	370..390	CDD:275368	9/19 (47%)
		COG5048	378..>463	CDD:227381	40/111 (36%)
		zf-H2C2_2	384..407	CDD:290200	13/22 (59%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		C2H2 Zn finger	426..447	CDD:275368	8/47 (17%)
		zf-H2C2_2	439..464	CDD:290200	12/24 (50%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
ZNF846	NP_001071092.1	KRAB	8..67	CDD:214630
		KRAB	8..45	CDD:279668
		COG5048	106..496	CDD:227381	98/331 (30%)
		C2H2 Zn finger	120..136	CDD:275368
		C2H2 Zn finger	200..220	CDD:275368	4/19 (21%)
		C2H2 Zn finger	228..248	CDD:275368	4/27 (15%)
		C2H2 Zn finger	256..276	CDD:275368	4/19 (21%)
		zf-H2C2_2	269..293	CDD:290200	9/30 (30%)
		C2H2 Zn finger	284..304	CDD:275368	6/19 (32%)
		zf-H2C2_2	296..321	CDD:290200	9/24 (38%)
		C2H2 Zn finger	312..332	CDD:275368	5/19 (26%)
		zf-H2C2_2	328..347	CDD:290200	6/18 (33%)
		zf-C2H2	338..360	CDD:278523	6/21 (29%)
		C2H2 Zn finger	340..360	CDD:275368	6/19 (32%)
		zf-H2C2_2	352..377	CDD:290200	11/24 (46%)
		C2H2 Zn finger	368..388	CDD:275368	9/19 (47%)
		zf-H2C2_2	381..405	CDD:290200	13/23 (57%)
		C2H2 Zn finger	396..416	CDD:275368	9/19 (47%)
		zf-H2C2_2	408..433	CDD:290200	10/24 (42%)
		C2H2 Zn finger	424..444	CDD:275368	3/19 (16%)
		zf-H2C2_2	437..461	CDD:290200	1/23 (4%)
		C2H2 Zn finger	452..472	CDD:275368	5/19 (26%)
		zf-H2C2_2	464..489	CDD:290200	12/24 (50%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		zf-H2C2_2	492..517	CDD:290200	3/13 (23%)
		C2H2 Zn finger	508..527	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010