DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2712 and ZNF425

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001001661.1	Gene:	ZNF425 / 155054	HGNCID:	20690	Length:	752	Species:	Homo sapiens

Alignment Length:	452	Identity:	114/452 - (25%)
Similarity:	176/452 - (38%)	Gaps:	98/452 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 DFC-----RSKKISAVNTRARLSTEIPEDFVLVL---------DDQEVTEYPAETIRDEEQLLVV 146
            |.|     :.:||....|....|..:.|..:|..         |.:::...|.||
Human   123 DLCAALRGKERKILLAQTATFQSPSLRETEILNKKVSITAYDPDKKDLRHKPRET---------- 177

  Fly   147 ESDEAESRLEAPI---------------VQEERLDIALEQHEDDLCEIVDDPDPEQRRSRLERSE 196
                 ..|||.|.               |:.:.|.......:..||......:..:.:|.|.|::
Human   178 -----PGRLEIPTGPRCYSCYVCRKVFQVRRDLLKHKRSHSKSQLCRYPKYKNSSRGKSELRRTQ 237

  Fly   197 PAL------QCPICGKQLARK----------------------RTFQYHMRLHGQPKIRQEDNDH 233
            ..|      ||..|.|....|                      :||:|...|.....:.:.:...
Human   238 RLLCQKKRFQCSECEKSYFLKGSLVTHQVVHTGQRPYPCPECDKTFRYRANLKKHLCLHRGERPF 302

  Fly   234 CIEEC-------LQVEPVLQAKAGEDVYEI--------VEKSAQTSATQKTLPSGSRPWKPLNPS 283
            |..||       .::...|:..:||..::.        :::..:...||.   ||.||:
Human   303 CCGECGRAFVQQCELTEHLRLHSGEKPFQCPQCDRCFRLKRGMKVHLTQH---SGKRPF------ 358

  Fly   284 LQCKICGKQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKV 348
             .|..||:..|...:.|.|.:.|....|:.|..||..|..:...|.|:.:|....|..||.|.|.
Human   359 -HCPECGRSFSRKAALKTHQRTHSEEKPFSCGECGRKFIYKIKLDEHIRVHTGEKPFSCPECNKS 422

  Fly   349 YRQASSLRTHLLIHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSNLIA 413
            :|...||:.|.|.|.|.:||:|..|.:....::..:.|...|:.:||..|..||:||...|.|..
Human   423 FRLKRSLKAHGLQHIGKRPFQCPECSRGFFWRNAMRAHQRLHSEQKPFPCAECGKRFTRPSKLAC 487

  Fly   414 HKRCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSERPFGCEQCGKSFKRRISLAIHRQSH 475
            |.|.|.::|..||..| |::|...|.|.:|:.||::|:||.|.:||:||:||..|..|.:.|
Human   488 HTRVHDRQKEFPCGEC-KKTFSQQSRLTQHLKVHTTEKPFSCAECGRSFRRRAHLTEHTRLH 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		C2H2 Zn finger	342..362	CDD:275368	9/19 (47%)
		zf-H2C2_2	354..379	CDD:290200	10/24 (42%)
		C2H2 Zn finger	370..390	CDD:275368	3/19 (16%)
		COG5048	378..>463	CDD:227381	32/84 (38%)
		zf-H2C2_2	384..407	CDD:290200	9/22 (41%)
		C2H2 Zn finger	398..418	CDD:275368	9/19 (47%)
		C2H2 Zn finger	426..447	CDD:275368	7/20 (35%)
		zf-H2C2_2	439..464	CDD:290200	12/24 (50%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
ZNF425	NP_001001661.1	KRAB	9..64	CDD:214630
		KRAB	9..48	CDD:279668
		C2H2 Zn finger	192..212	CDD:275368	2/19 (11%)
		C2H2 Zn finger	248..268	CDD:275368	4/19 (21%)
		C2H2 Zn finger	276..296	CDD:275368	4/19 (21%)
		C2H2 Zn finger	304..324	CDD:275368	3/19 (16%)
		C2H2 Zn finger	332..352	CDD:275368	1/19 (5%)
		COG5048	355..731	CDD:227381	71/202 (35%)
		zf-C2H2	358..380	CDD:278523	6/28 (21%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		zf-H2C2_2	401..423	CDD:290200	8/21 (38%)
		C2H2 Zn finger	416..432	CDD:275368	7/15 (47%)
		C2H2 Zn finger	444..464	CDD:275368	3/19 (16%)
		C2H2 Zn finger	472..492	CDD:275368	9/19 (47%)
		C2H2 Zn finger	500..520	CDD:275368	7/20 (35%)
		C2H2 Zn finger	528..548	CDD:275368	9/19 (47%)
		zf-H2C2_2	540..564	CDD:290200	3/9 (33%)
		C2H2 Zn finger	556..576	CDD:275368
		C2H2 Zn finger	584..604	CDD:275368
		zf-H2C2_2	597..619	CDD:290200
		C2H2 Zn finger	612..632	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368
		zf-H2C2_2	653..675	CDD:290200
		C2H2 Zn finger	668..688	CDD:275368
		zf-H2C2_2	680..705	CDD:290200
		C2H2 Zn finger	696..716	CDD:275368
		C2H2 Zn finger	724..744	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146754
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030