DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2712 and Zfp37

DIOPT Version :9

Sequence 1:	NP_570028.1	Gene:	CG2712 / 31267	FlyBaseID:	FBgn0024975	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_478116.2	Gene:	Zfp37 / 115768	RGDID:	620723	Length:	626	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	133/507 - (26%)
Similarity:	201/507 - (39%)	Gaps:	125/507 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LEAELFLPHHICPDCVAKLRLSLEFKRSVHRMDRILRQSHADFCRSKKISAVNTRARLSTEIPED 119
            |...|.||..|......|...:.|:::|       |..|.:|..|.:    ::||.:.. :.|.:
  Rat   178 LNQNLDLPSQIKISAKKKPDTANEYRKS-------LSHSASDVNRDE----ISTRKKCD-KSPNN 230

  Fly   120 FVLVLDDQEVTEYPAETIRDEEQLLVVESDEAESRLEAPIVQEERLDIALEQHEDDLCEIVDDPD 184
            .:....|:..|....|.:               .|..|...:|:::...
  Rat   231 KLFGKGDKNQTGKKCEKV---------------CRHSASHTKEDKIHTG---------------- 264

  Fly   185 PEQRRSRL---ERSEPA------LQCPICGKQLARKRTFQYHMRLHGQPK--------IRQEDND 232
             |:|:|..   .:|:.|      .:|..|||.|:.|:....|.|.|...|        |......
  Rat   265 -EKRKSPCRSPSKSDKAPGSGKPYECNQCGKVLSHKQGLLDHQRTHTGEKPYECNECGIAFSQKS 328

  Fly   233 HCIEECLQVEPVLQAKAGEDVYEIVE-------KSAQTSATQKTLPSGSRPWKPLNPSLQCKICG 290
            |.:..       .:...||..||.|:       |.|.|...:  :.:|.:|:|       |..||
  Rat   329 HLVVH-------QRTHTGEKPYECVQCGKAHGHKHALTDHLR--IHTGEKPYK-------CNECG 377

  Fly   291 KQLSTNNSFKYHMQLHGTATPYVCTICGESFKTRNARDGHVTLHDRNNPNRCPTCFKVYRQASSL 355
            |....:::...|::.|....||.|..||:||:..::...||..|....|..|..|.|.::..|||
  Rat   378 KTFRHSSNLMQHIRSHTGEKPYECKECGKSFRYNSSLTEHVRTHTGEIPYECNECGKAFKYGSSL 442

  Fly   356 RTHLLIHSGIKPFECSICGKRLTQKSGYKKHMLTHTGEKPHGCDICGRRFRYSSN---------- 410
            ..|:.||:|.|||||:.|||..::||....|..|||.|||:.|..||:.|.:||:
  Rat   443 TKHMRIHTGEKPFECTECGKTFSKKSHLVIHQRTHTKEKPYKCKECGKAFGHSSSLTYHLRTHTG 507

  Fly   411 ------------------LIAHKRCHSQEKPHPCPVCQKRSFGSTSELNRHMLVHSSERPFGCEQ 457
                              |..|:|.|:.|||:.|..|.| :|...|.|..|...|:.|:||.|.:
  Rat   508 DCPFECNQCGKAFKQIEGLTQHQRVHTGEKPYECVECGK-AFSQKSHLIVHQRTHTGEKPFECYE 571

  Fly   458 CGKSFKRRISLAIHRQSH------------KAGRQRRRAEHEVGVQLEEQDE 497
            |||:|..:..|.||::||            ||.:|.......:.:..|||.:
  Rat   572 CGKAFNAKSQLVIHQRSHTGEKPYECVECGKAFKQNASLTRHMKIHSEEQSQ 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2712	NP_570028.1	zf-AD	13..92	CDD:214871	9/36 (25%)
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		zf-H2C2_2	354..379	CDD:290200	14/24 (58%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		COG5048	378..>463	CDD:227381	37/112 (33%)
		zf-H2C2_2	384..407	CDD:290200	11/22 (50%)
		C2H2 Zn finger	398..418	CDD:275368	9/47 (19%)
		C2H2 Zn finger	426..447	CDD:275368	7/20 (35%)
		zf-H2C2_2	439..464	CDD:290200	11/24 (46%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
Zfp37	NP_478116.2	KRAB_A-box	28..68	CDD:143639
		KRAB	41..89	CDD:214630
		COG5048	124..518	CDD:227381	99/399 (25%)
		C2H2 Zn finger	243..262	CDD:275368	4/33 (12%)
		C2H2 Zn finger	289..309	CDD:275368	8/19 (42%)
		zf-H2C2_2	302..326	CDD:290200	5/23 (22%)
		C2H2 Zn finger	317..337	CDD:275368	2/26 (8%)
		zf-H2C2_2	329..351	CDD:290200	6/28 (21%)
		C2H2 Zn finger	345..365	CDD:275368	4/21 (19%)
		zf-H2C2_2	357..382	CDD:290200	9/33 (27%)
		zf-C2H2	371..393	CDD:278523	6/28 (21%)
		C2H2 Zn finger	373..393	CDD:275368	5/19 (26%)
		zf-H2C2_2	385..410	CDD:290200	9/24 (38%)
		C2H2 Zn finger	401..421	CDD:275368	7/19 (37%)
		zf-H2C2_2	413..438	CDD:290200	7/24 (29%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		zf-H2C2_2	441..465	CDD:290200	14/23 (61%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		zf-H2C2_2	469..492	CDD:290200	10/22 (45%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		C2H2 Zn finger	513..533	CDD:275368	3/19 (16%)
		zf-H2C2_2	526..550	CDD:290200	11/24 (46%)
		C2H2 Zn finger	541..561	CDD:275368	7/20 (35%)
		zf-H2C2_2	553..577	CDD:290200	10/23 (43%)
		COG5048	565..>626	CDD:227381	18/59 (31%)
		C2H2 Zn finger	569..589	CDD:275368	8/19 (42%)
		zf-H2C2_2	582..606	CDD:290200	7/23 (30%)
		C2H2 Zn finger	597..617	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24381
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100