DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttm50 and CTDP1

DIOPT Version :9

Sequence 1:	NP_001303557.1	Gene:	ttm50 / 31266	FlyBaseID:	FBgn0250874	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_004706.3	Gene:	CTDP1 / 9150	HGNCID:	2498	Length:	961	Species:	Homo sapiens

Alignment Length:	316	Identity:	70/316 - (22%)
Similarity:	104/316 - (32%)	Gaps:	108/316 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 PAAAPALFSILHTARGYSSTTKQEAGATGPNDAPEVAPNAPLLAKLFPQTSPEVDSNAEQER--- 127
            |.|||.....|  |:|.|....:.|..:.|.:|   .|.|..     |...||:....|.||
Human   487 PKAAPEGAGAL--AQGSSLEPGRPAAPSLPGEA---EPGAHA-----PDKEPELGGQEEGERDGL 541

  Fly   128 --------KKREEEEEKENERAWKRMKLGFAIFGGSAVAAGFWAVYEFGKPEVDPNGQPIEDEFT 184
                    .::|.|.|.:|...             |.|.||         ..:|.:.:..|:|.|
Human   542 CGLGNGCADRKEAETESQNSEL-------------SGVTAG---------ESLDQSMEEEEEEDT 584

  Fly   185 HKPLVQQYLQRMWKSIH---------YYQRMIQE-PSRAKLLPDPLKPPYVQPRYTLVLEMKDVL 239
            .:.....||:.:...:|         |..:.|:| |...|::|: ||...          :.||.
Human   585 DEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRKIVPE-LKSKV----------LADVA 638

  Fly   240 VHPDWTYQTGWRFKKRPGVDHFLAECAKDFEIVVFTAEQGMTVFPILDALDPNGYIMYRLVRDAT 304
            :.....:.|.:..:|.....|..|..||....:|.:.          ||.|           .||
Human   639 IIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSP----------DAPD-----------RAT 682

  Fly   305 HFVD--------------GH-HVKNLDNLNRDLKKVIVVDWDANATKMHP---DNT 342
            |.:.              || ||.|.|.|...|::     ||....::.|   |:|
Human   683 HLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLER-----WDKVEEQLFPLRDDHT 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm50	NP_001303557.1	CPDc	227..355	CDD:214729	28/134 (21%)
CTDP1	NP_004706.3	Biotinyl_lipoyl_domains	21..111	CDD:299706
		FCP1_euk	177..323	CDD:131304
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..589		31/133 (23%)
		BRCT	636..716	CDD:237994	22/100 (22%)
		FCP1_C	716..961	CDD:286402	5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..752		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	780..949
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900