DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttm50 and Timm50

DIOPT Version :9

Sequence 1:	NP_001303557.1	Gene:	ttm50 / 31266	FlyBaseID:	FBgn0250874	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	XP_003748854.1	Gene:	Timm50 / 687295	RGDID:	1587684	Length:	353	Species:	Rattus norvegicus

Alignment Length:	350	Identity:	148/350 - (42%)
Similarity:	206/350 - (58%)	Gaps:	21/350 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 AAAPALFSILHTARGYSSTTKQEAGATGPNDAPEVAPNAPLLAKLFPQTSPEVDSNAEQERKKRE 131
            ||:.||||.|.:.        ...||.|.  ...:||..|..    |:...|:.:....:.:..:
  Rat     2 AASAALFSRLRSG--------LRVGARGL--CTRLAPPPPRT----PEQVTEIANRGGSKTQGPQ 52

  Fly   132 EEEEKENERAWKRMKLGFA-IFGGSAVAAGFWAVYEFGKPEVDPNGQPIEDEFTHKPLVQQYLQR 195
            .:...|.....|::.|..| :.|.....:   .||.||...||.||..|.|||...|::.|.|:|
  Rat    53 HQPGSEGPSYAKKVALWIAGLLGAGGTVS---IVYIFGNNPVDENGTKIPDEFDSDPILVQQLRR 114

  Fly   196 MWKSIHYYQRMIQEPSRAKLLPDPLKPPYVQPRYTLVLEMKDVLVHPDWTYQTGWRFKKRPGVDH 260
            .:|....|::||.||:...||||||:.||.||.||||||:..||:||:|:..||||||||||::.
  Rat   115 TYKYFKDYRQMIIEPTSPCLLPDPLREPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIET 179

  Fly   261 FLAECAKDFEIVVFTAEQGMTVFPILDALDPNGYIMYRLVRDATHFVDGHHVKNLDNLNRDLKKV 325
            ...:.|..:|||:||:|.|||.||::|::||:|:|.|||.||||.:::|||||::..||||..:|
  Rat   180 LFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMEGHHVKDISCLNRDPARV 244

  Fly   326 IVVDWDANATKMHPDNTFGLARWHGNDDDGQLLDLIAFLKIIAQNNVDDVREVLHYYRQFDDPIN 390
            :|||....|.::.|.|...|..|.||.||..||||.||||.||.|.|:|||.||.:|...|||:.
  Rat   245 VVVDCKKEAFRLQPFNGVALRPWDGNSDDRVLLDLSAFLKTIALNQVEDVRTVLEHYALEDDPLE 309

  Fly   391 QFRENQRKLAEQMLEAERI-EQSKT 414
            .|::.|.:|.::  |.:|: |.||:
  Rat   310 AFKQRQSRLEQE--EQQRLAELSKS 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm50	NP_001303557.1	CPDc	227..355	CDD:214729	67/127 (53%)
Timm50	XP_003748854.1	HAD_FCP1-like	147..262	CDD:319823	61/114 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347802
Domainoid	1	1.000	178	1.000	Domainoid score	I3459
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H57031
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3030
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1142452at2759
OrthoFinder	1	1.000	-	-		FOG0003614
OrthoInspector	1	1.000	-	-		otm45022
orthoMCL	1	0.900	-	-		OOG6_102279
Panther	1	1.100	-	-	LDO	PTHR12210
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2489
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800