DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttm50 and Timm50

DIOPT Version :9

Sequence 1:	NP_001303557.1	Gene:	ttm50 / 31266	FlyBaseID:	FBgn0250874	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_079892.1	Gene:	Timm50 / 66525	MGIID:	1913775	Length:	353	Species:	Mus musculus

Alignment Length:	350	Identity:	148/350 - (42%)
Similarity:	206/350 - (58%)	Gaps:	21/350 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 AAAPALFSILHTARGYSSTTKQEAGATGPNDAPEVAPNAPLLAKLFPQTSPEVDSNAEQERKKRE 131
            ||:.||||.|.:.        ...||.|.  ...:||..|..    |:...|:.:....:.:..:
Mouse     2 AASAALFSRLRSG--------LRVGARGL--CTRLAPPPPRT----PEQVTEIANRGGSKAQGPQ 52

  Fly   132 EEEEKENERAWKRMKLGFA-IFGGSAVAAGFWAVYEFGKPEVDPNGQPIEDEFTHKPLVQQYLQR 195
            .:...|.....|::.|..| :.|.....:   .||.||...||.||..|.|||...|::.|.|:|
Mouse    53 HQPGSEGPSYAKKIALWIAGLLGAGGTVS---IVYIFGNNPVDENGTKIPDEFDSDPILVQQLRR 114

  Fly   196 MWKSIHYYQRMIQEPSRAKLLPDPLKPPYVQPRYTLVLEMKDVLVHPDWTYQTGWRFKKRPGVDH 260
            .:|....|::||.||:...||||||:.||.||.||||||:..||:||:|:..||||||||||::.
Mouse   115 TYKYFKDYRQMIIEPTSPCLLPDPLREPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIET 179

  Fly   261 FLAECAKDFEIVVFTAEQGMTVFPILDALDPNGYIMYRLVRDATHFVDGHHVKNLDNLNRDLKKV 325
            ...:.|..:|||:||:|.|||.||::|::||:|:|.|||.||||.:::|||||::..||||..:|
Mouse   180 LFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMEGHHVKDISCLNRDPARV 244

  Fly   326 IVVDWDANATKMHPDNTFGLARWHGNDDDGQLLDLIAFLKIIAQNNVDDVREVLHYYRQFDDPIN 390
            :|||....|.::.|.|...|..|.||.||..||||.||||.||.|.|:|||.||.:|...|||:.
Mouse   245 VVVDCKKEAFRLQPFNGVALRPWDGNSDDRVLLDLSAFLKTIALNQVEDVRTVLEHYALEDDPLE 309

  Fly   391 QFRENQRKLAEQMLEAERI-EQSKT 414
            .|::.|.:|.::  |.:|: |.||:
Mouse   310 AFKQRQSRLEQE--EQQRLAELSKS 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm50	NP_001303557.1	CPDc	227..355	CDD:214729	67/127 (53%)
Timm50	NP_079892.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..59		5/39 (13%)
Timm50	NP_079892.1	NIF	148..295	CDD:281081	80/146 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844427
Domainoid	1	1.000	178	1.000	Domainoid score	I3538
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H57031
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3098
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S1903
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003614
OrthoInspector	1	1.000	-	-		otm42956
orthoMCL	1	0.900	-	-		OOG6_102279
Panther	1	1.100	-	-	LDO	PTHR12210
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1522
SonicParanoid	1	1.000	-	-		X2489
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.730