DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttm50 and CTDSPL2

DIOPT Version :9

Sequence 1:	NP_001303557.1	Gene:	ttm50 / 31266	FlyBaseID:	FBgn0250874	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_057480.2	Gene:	CTDSPL2 / 51496	HGNCID:	26936	Length:	466	Species:	Homo sapiens

Alignment Length:	334	Identity:	80/334 - (23%)
Similarity:	125/334 - (37%)	Gaps:	112/334 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SSTTKQEAGATGPNDAPEVAPN----------------APLLAKLFPQTSPEVDSNAEQERKKRE 131
            :|||....||...|.|.:|.|:                .||.|.:.|      ||.......:..
Human   189 TSTTTSTNGAAYSNQAVQVRPSLNNGLEEAEETVNRDIPPLTAPVTP------DSGYSSAHAEAT 247

  Fly   132 EEEEKENERAWKRMKLGFAIFGGSAVAAGFWAVYEFGKPEVDP-----NGQPI-EDEFTHKPLVQ 190
            .||:                          |.|:       ||     :..|: |::...||.:
Human   248 YEED--------------------------WEVF-------DPYYFIKHVPPLTEEQLNRKPAL- 278

  Fly   191 QYLQRMWKSIHYYQRMIQEPSRAKLLPDPLKPPYVQPRYTLVLEMKDVLVH-------------- 241
                                        |||.... |.::|||::.:.|||
Human   279 ----------------------------PLKTRST-PEFSLVLDLDETLVHCSLNELEDAALTFP 314

  Fly   242 ---PDWTYQTGWRFKKRPGVDHFLAECAKDFEIVVFTAEQGMTVFPILDALDPNGYIM-YRLVRD 302
               .|..||...|.  ||....||...::.:||::|||.:.:....:|:.|||...:: :||.|:
Human   315 VLFQDVIYQVYVRL--RPFFREFLERMSQMYEIILFTASKKVYADKLLNILDPKKQLVRHRLFRE 377

  Fly   303 ATHFVDGHHVKNLDNLNRDLKKVIVVDWDANATKMHPDNTFGLARWHGNDDDGQLLDLIAFLKII 367
            ....|.|:::|:|:.|.|||.|.|::|....|......|...:..|..:.:|.:||.||.||:.:
Human   378 HCVCVQGNYIKDLNILGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDNELLKLIPFLEKL 442

  Fly   368 AQNNVDDVR 376
            .:.| :|||
Human   443 VELN-EDVR 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm50	NP_001303557.1	CPDc	227..355	CDD:214729	41/145 (28%)
CTDSPL2	NP_057480.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..240		6/25 (24%)
		HIF-SF_euk	287..448	CDD:274055	48/163 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810