DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttm50 and timm50

DIOPT Version :9

Sequence 1:	NP_001303557.1	Gene:	ttm50 / 31266	FlyBaseID:	FBgn0250874	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_956959.1	Gene:	timm50 / 393638	ZFINID:	ZDB-GENE-040426-1618	Length:	387	Species:	Danio rerio

Alignment Length:	370	Identity:	158/370 - (42%)
Similarity:	218/370 - (58%)	Gaps:	25/370 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 AAAPALFSILHTARGYSSTTKQEAGATGPNDAPEVAPNAPLLAKLFPQTSPEVDSNAEQERKKRE 131
            :.||.|..::   |..|:.| ..:.|||......:........|...|..||.:.:..::.::.|
Zfish    27 STAPPLLDVV---RPLSADT-SSSSATGGLAQAILQERLQQQQKSQEQPPPEGEDSGHKQDEQGE 87

  Fly   132 EEEEKENERAWKRMKLGFAIFGGSAVAAGFWAVYEFGKPEVDPNGQPIEDEFTHK-PLVQQYLQR 195
            ::::|||....|:|.|..|...|.....|.  ||.||...||..|..|.|||.:. |::|| |:|
Zfish    88 DKKQKENTAYAKKMVLRLAGIMGLGGTVGI--VYIFGSNSVDEQGNKIPDEFDNDVPVIQQ-LRR 149

  Fly   196 MWKSIHYYQRMIQEPSRAKLLPDPLKPPYVQPRYTLVLEMKDVLVHPDWTYQTGWRFKKRPGVDH 260
            .:|....|::||.||:..|||||||:.||.||.||||||:.|||:||:|:..||||||||||:|:
Zfish   150 TFKYFKDYRQMIIEPTSPKLLPDPLREPYYQPPYTLVLELTDVLLHPEWSLATGWRFKKRPGIDY 214

  Fly   261 FLAECAKDFEIVVFTAEQGMTVFPILDALDPNGYIMYRLVRDATHFVDGHHVKNLDNLNRDLKKV 325
            ...:.|..:|||:||:|.|||.:|::|::||.|::||||.||||.:::|||||::..||||..||
Zfish   215 LFQQLAPLYEIVIFTSETGMTAYPLIDSIDPQGFVMYRLFRDATRYMEGHHVKDVSCLNRDTSKV 279

  Fly   326 IVVDWDANATKMHPDNTFGLARWHGNDDDGQLLDLIAFLKIIAQNNVDDVREVLHYYRQFDDPIN 390
            ||||....|..:.|.|...|.:|.||.:|..|.||.||||.||.:.|:|||.||..|...:|||.
Zfish   280 IVVDCKREAFGLQPFNGLALCKWDGNSEDRTLYDLAAFLKTIATSGVEDVRSVLENYAHEEDPIE 344

  Fly   391 QFRENQRKLAEQMLEAERI-EQSKTKPMVKQ-----------WSR 423
            .|:..|.:||.:  |.:|| |.::.|   ||           |||
Zfish   345 AFKRRQAQLARE--EEQRISEMAQQK---KQGFSLGTIAGRFWSR 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm50	NP_001303557.1	CPDc	227..355	CDD:214729	69/127 (54%)
timm50	NP_956959.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..93		5/31 (16%)
timm50	NP_956959.1	NIF	183..330	CDD:281081	80/146 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589340
Domainoid	1	1.000	183	1.000	Domainoid score	I3366
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H57031
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2930
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1142452at2759
OrthoFinder	1	1.000	-	-		FOG0003614
OrthoInspector	1	1.000	-	-		otm26612
orthoMCL	1	0.900	-	-		OOG6_102279
Panther	1	1.100	-	-	LDO	PTHR12210
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1522
SonicParanoid	1	1.000	-	-		X2489
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790