DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttm50 and ttm2

DIOPT Version :9

Sequence 1:	NP_001303557.1	Gene:	ttm50 / 31266	FlyBaseID:	FBgn0250874	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_612023.1	Gene:	ttm2 / 38049	FlyBaseID:	FBgn0035124	Length:	409	Species:	Drosophila melanogaster

Alignment Length:	322	Identity:	204/322 - (63%)
Similarity:	257/322 - (79%)	Gaps:	3/322 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 LLAKLFPQTSPEVDSNAEQERKKREEEEE-KENERAWKRMKLGFAIFGGSAVAAGFWAVYEFGKP 170
            :|.|||||||.|.:....:||:|.||||| ||.|||::||||||.:||..::...|||:|.:|:|
  Fly    87 ILTKLFPQTSEESNDEESRERRKLEEEEEQKELERAFRRMKLGFGLFGIGSMLFSFWAIYFYGRP 151

  Fly   171 EVDPNGQPIEDEFTHKPLVQQYLQRMWKSIHYYQRMIQEPSRAKLLPDPLKPPYVQPRYTLVLEM 235
            .:|.:|..:.|||:..|.:||.:.|.|||::.:||..:||||.|||||||:||||||.||||||:
  Fly   152 SLDEHGNEVIDEFSCLPQMQQLMWRTWKSVNRFQRFFKEPSRKKLLPDPLQPPYVQPPYTLVLEI 216

  Fly   236 KDVLVHPDWTYQTGWRFKKRPGVDHFLAECAKDFEIVVFTAEQGMTVFPILDALDPNGYIMYRLV 300
            |||||||||||:||||||||||||.||.||||.|||||:|||||:||||::|||||||.||||||
  Fly   217 KDVLVHPDWTYETGWRFKKRPGVDVFLKECAKYFEIVVYTAEQGVTVFPLVDALDPNGCIMYRLV 281

  Fly   301 RDATHFVDGHHVKNLDNLNRDLKKVIVVDWDANATKMHPDNTFGLARWHGNDDDGQLLDLIAFLK 365
            ||:|||..|||||||||||||||:|:|||||.|:||.||.|:|.:.||.|||:|..|.:|.:||.
  Fly   282 RDSTHFDGGHHVKNLDNLNRDLKRVVVVDWDRNSTKFHPSNSFSIPRWSGNDNDTTLFELTSFLS 346

  Fly   366 IIAQNNVDDVREVLHYYRQFDDPINQFRENQRKLAEQMLEAERIEQ-SKTKPMVKQWSRNIL 426
            ::..:.:|||||||.||.||.|.::|||||||||.| ::.||.:|: ||::|:||.|:|..:
  Fly   347 VLGTSEIDDVREVLQYYNQFSDSLSQFRENQRKLGE-LMHAEEVEKTSKSRPVVKNWTRGFI 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm50	NP_001303557.1	CPDc	227..355	CDD:214729	101/127 (80%)
ttm2	NP_612023.1	CPDc	208..336	CDD:214729	101/127 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459142
Domainoid	1	1.000	132	1.000	Domainoid score	I1664
eggNOG	1	0.900	-	-		E1_COG5190
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I1782
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S1903
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1142452at2759
OrthoFinder	1	1.000	-	-		FOG0003614
OrthoInspector	1	1.000	-	-		otm26612
orthoMCL	1	0.900	-	-		OOG6_102279
Panther	1	1.100	-	-	P	PTHR12210
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1522
SonicParanoid	1	1.000	-	-		X2489
	13	12.780