DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttm50 and UBLCP1

DIOPT Version :9

Sequence 1:	NP_001303557.1	Gene:	ttm50 / 31266	FlyBaseID:	FBgn0250874	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_659486.2	Gene:	UBLCP1 / 134510	HGNCID:	28110	Length:	318	Species:	Homo sapiens

Alignment Length:	240	Identity:	55/240 - (22%)
Similarity:	92/240 - (38%)	Gaps:	49/240 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 PEVDP--NGQPIEDEFTHKPLVQQYLQRMWKSIHYYQRMIQEPSRAKLLPDPLKPPYVQPRYTLV 232
            |:.|.  |...||||.......::.|.::.:.:..|:..|..|.|             :.:..||
Human    90 PDNDDVVNDFDIEDEVVEVENREENLLKISRRVKEYKVEILNPPR-------------EGKKLLV 141

  Fly   233 LEMKDVLVHPDWTYQTGWRFKKRPGVDHFLAECAKDFEIVVFTAEQGMTVFPILDALDPNGYIMY 297
            |::...|.......:||... .||.:..||....:|::||:::|.....:...:..|..:....|
Human   142 LDVDYTLFDHRSCAETGVEL-MRPYLHEFLTSAYEDYDIVIWSATNMKWIEAKMKELGVSTNANY 205

  Fly   298 RLVRDATHFVDGHHVKNLDNLNRDL-------------------KKVIVVDWDANATKMHPDNTF 343
            ::    |..:|...:..:....|.|                   |..|:.|.......|:|.|
Human   206 KI----TFMLDSAAMITVHTPRRGLIDVKPLGVIWGKFSEFYSKKNTIMFDDIGRNFLMNPQN-- 264

  Fly   344 GL-----ARWHGN-DDDGQLLDLIAFLKIIAQNNVDDVREVLHYY 382
            ||     .:.|.| |.|.:||.|..:||.||:  :||..::.|.|
Human   265 GLKIRPFMKAHLNRDKDKELLKLTQYLKEIAK--LDDFLDLNHKY 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm50	NP_001303557.1	CPDc	227..355	CDD:214729	31/152 (20%)
UBLCP1	NP_659486.2	Ubl_UBLCP1	3..77	CDD:340511
		HAD_IIID1	117..311	CDD:131299	47/213 (22%)
		Phosphatase	133..294		38/180 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5190
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900