DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ttm50 and timm50

DIOPT Version :9

Sequence 1:	NP_001303557.1	Gene:	ttm50 / 31266	FlyBaseID:	FBgn0250874	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001120038.1	Gene:	timm50 / 100145004	XenbaseID:	XB-GENE-963112	Length:	368	Species:	Xenopus tropicalis

Alignment Length:	354	Identity:	150/354 - (42%)
Similarity:	202/354 - (57%)	Gaps:	25/354 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 RGYSSTTKQEAGATGPNDAPEVAPNAPLLAKL-FPQTSPEVDSNAEQERKKREEEEEKENERAWK 143
            |.:||....|.|.||          |.|..|| ..:.....||:..:|::|:    :|||....|
Frog    28 RAFSSEQGAEGGLTG----------AVLQEKLQRRENEASSDSSGSEEKQKK----QKENAANAK 78

  Fly   144 RMKLGFAIFGGSAVAAGFWAVYEFGKPEVDPNGQPIEDEFTHKPLVQQYLQRMWKSIHYYQRMIQ 208
            |..|..|  |...||.....||.||...||..|..|.|||...|.|.|.::|.:|....|::||.
Frog    79 RFLLRAA--GLLGVAGSGSLVYIFGSNSVDEQGNKIPDEFDSDPPVVQQIRRTYKYFIDYRQMII 141

  Fly   209 EPSRAKLLPDPLKPPYVQPRYTLVLEMKDVLVHPDWTYQTGWRFKKRPGVDHFLAECAKDFEIVV 273
            ||:..||||||||.||.||.||||||:.|||:||:|:..||||||||.|:|:...:.|..:|||:
Frog   142 EPTSPKLLPDPLKEPYYQPPYTLVLELTDVLLHPEWSLSTGWRFKKRAGIDNLFQQLAPLYEIVI 206

  Fly   274 FTAEQGMTVFPILDALDPNGYIMYRLVRDATHFVDGHHVKNLDNLNRDLKKVIVVDWDANATKMH 338
            ||:|.|:|.||::|.:||:|::.|||.||||.:.||||||::..||||...|::||....|.|:.
Frog   207 FTSETGLTAFPLIDNVDPHGFVSYRLFRDATRYTDGHHVKDISCLNRDPSHVVIVDCKREAFKLQ 271

  Fly   339 PDNTFGLARWHGNDDDGQLLDLIAFLKIIAQNNVDDVREVLHYYRQFDDPINQFRENQRKL--AE 401
            |.|...:.:|.|:.:|..|.||.||||.||.:.|.|||.||..|...:||:..|:..|.:|  .|
Frog   272 PYNGLAIKKWDGSSEDRALYDLTAFLKTIAVSGVSDVRSVLENYALEEDPLEAFKRRQTQLEQEE 336

  Fly   402 QMLEAERIEQSKTKPMV------KQWSRN 424
            |...|:..:.||.:.:.      :.|.|:
Frog   337 QQRLADMSQLSKRQTLSLGSFTGRLWPRS 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ttm50	NP_001303557.1	CPDc	227..355	CDD:214729	64/127 (50%)
timm50	NP_001120038.1	LPLAT	<64..>128	CDD:388412	26/69 (38%)
timm50	NP_001120038.1	HAD_FCP1-like	161..278	CDD:319823	61/116 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3648
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H57031
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3026
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1142452at2759
OrthoFinder	1	1.000	-	-		FOG0003614
OrthoInspector	1	1.000	-	-		otm48079
Panther	1	1.100	-	-	LDO	PTHR12210
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1522
SonicParanoid	1	1.000	-	-		X2489
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190