DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF623

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_055604.3	Gene:	ZNF623 / 9831	HGNCID:	29084	Length:	536	Species:	Homo sapiens

Alignment Length:	419	Identity:	118/419 - (28%)
Similarity:	190/419 - (45%)	Gaps:	80/419 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 LSEEEHQLAQSGDQQEEHITM--------ESVHEFQPAEV-------------------EYVTIK 215
            :||:|:....:.|:    :|:        |.|||.:..|:                   :.||:.
Human    24 ISEDENSHRTTSDR----LTVMELPSPESEEVHEPRLGELLGNPEGQSLGSSPSQDRGCKQVTVT 84

  Fly   216 N------EFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGD------ 268
            :      |...:.|:.....::|..     :|..|..:|..|....::.| :|.....|
Human    85 HWKIQTGETAQVCTKSGRNHILNSD-----LLLLQRELIEGEANPCDICG-KTFTFNSDLVRHRI 143

  Fly   269 -----------------GREEHLLPEAE----------DVCEDEDFLEES--LDSAPPTAGEALP 304
                             |:..||:....          :|| .:||:..|  ::.....:||. |
Human   144 SHAGEKPYTCDQCGKGFGQSSHLMEHQRIHTGERLYVCNVC-GKDFIHYSGLIEHQRVHSGEK-P 206

  Fly   305 YVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRF 369
            :.|..|.|||.....|.:|.|.|..|:.:||:||||..........|...||..:|::|:.||:.
Human   207 FKCAQCGKAFCHSSDLIRHQRVHTRERPFECKECGKGFSQSSLLIRHQRIHTGERPYECNECGKS 271

  Fly   370 YRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQ 434
            :..:|||..|.:.|.|.|.|.|.:||:.:.....|..|:..||||||:.|:.|.||:..||.|.|
Human   272 FIRSSSLIRHYQIHTEVKQYECKECGKAFRHRSDLIEHQRIHTGERPFECNECGKAFIRSSKLIQ 336

  Fly   435 HKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEK 499
            |:..|||::.:.|..||...||.|.:.:|..:|:|.|.::|:.||.||..:|.|..|.::|:||:
Human   337 HQRIHTGERPYVCNECGKRFSQTSNFTQHQRIHTGEKLYECNECGKAFFLSSYLIRHQKIHTGER 401

  Fly   500 PFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            .::|:.|.|||..|..|..|.::|:.:.|
Human   402 VYECKECGKAFLQKAHLTEHQKIHSGDRP 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	58/153 (38%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	54/135 (40%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	8/22 (36%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZNF623	NP_055604.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..77		1/19 (5%)
		COG5048	123..494	CDD:227381	99/311 (32%)
		C2H2 Zn finger	125..145	CDD:275368	3/20 (15%)
		C2H2 Zn finger	153..173	CDD:275368	3/19 (16%)
		C2H2 Zn finger	181..201	CDD:275368	5/20 (25%)
		C2H2 Zn finger	209..229	CDD:275368	8/19 (42%)
		C2H2 Zn finger	237..257	CDD:275368	6/19 (32%)
		C2H2 Zn finger	265..285	CDD:275368	7/19 (37%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		C2H2 Zn finger	321..341	CDD:275368	9/19 (47%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	377..397	CDD:275368	8/19 (42%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
		C2H2 Zn finger	433..453	CDD:275368
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	489..509	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910