DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZSCAN12

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001156863.1	Gene:	ZSCAN12 / 9753	HGNCID:	13172	Length:	611	Species:	Homo sapiens

Alignment Length:	575	Identity:	150/575 - (26%)
Similarity:	248/575 - (43%)	Gaps:	145/575 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 YCTGLSFEPQDGAAMPQHICLHCLQLLEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPN 111
            :|...:..|::..:..:.:| |  |.|....:.|..::   |||.|          .:..|..|.
Human    52 FCYQETSGPREALSRLRELC-H--QWLRPETHTKEQIL---ELLVL----------EQFLTILPE 100

  Fly   112 QSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEV---- 172
            :.|...|:|.. :|.||.|.:         :.:|:.||.|...::...| .|:|.||.|.|
Human   101 ELQAWVQEQHP-ESGEEVVTV---------LEDLERELDEPGEQVSVHT-GEQEMFLQETVRLRK 154

  Fly   173 DQDDELS------EEEHQLAQSGDQQEEHITMESVHEF--------------------------- 204
            :.:..:|      :.:::..:...|||:.:.:|:.:|:
Human   155 EGEPSMSLQSMKAQPKYESPELESQQEQVLDVETGNEYGNLKQEVSEEMEPHGKTSSKFENDMSK 219

  Fly   205 -----QPAEVEYVTIKNEFETIVTEEDEFEVMNDSGA----------HDAILDCQMIVIPAEGAI 254
                 :..|.|.:|   |..:..:.||:....:::|.          |..|  |.
Human   220 SARCGETREPEEIT---EEPSACSREDKQPTCDENGVSLTENSDHTEHQRI--CP---------- 269

  Fly   255 DEVIGEETLELEGDGR----EEHLLPEAEDVCEDEDFLEESLDSAPPTAGEAL------------ 303
                |||:...:..|:    ..||:........|..:..|....|  ..|..:
Human   270 ----GEESYGCDDCGKAFSQHSHLIEHQRIHTGDRPYKCEECGKA--FRGRTVLIRHKIIHTGEK 328

  Fly   304 PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLK-----------HLRN--YK------ 349
            ||.|..|.|||.:...||||.|.|..||.|.|.:|||...           |.|:  |:
Human   329 PYKCNECGKAFGRWSALNQHQRLHTGEKHYHCNDCGKAFSQKAGLFHHIKIHTRDKPYQCTQCNK 393

  Fly   350 ---------EHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLR 405
                     :|...||..||::|:.||:.:...|||..|:..|.::|.|.|.:||:.::. ..|.
Human   394 SFSRRSILTQHQGVHTGAKPYECNECGKAFVYNSSLVSHQEIHHKEKCYQCKECGKSFSQ-SGLI 457

  Fly   406 RHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGV 470
            :|:..||||:||.||:|:||:...:||.:|:..|||::.:.|:.||...:|:|...:|..:|:|.
Human   458 QHQRIHTGEKPYKCDVCEKAFIQRTSLTEHQRIHTGERPYKCDKCGKAFTQRSVLTEHQRIHTGE 522

  Fly   471 KAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNK 525
            :.:|||.||:||...::|..|.|:|:||||::|:.|.|||..:..|:.|.|:||:
Human   523 RPYKCDECGNAFRGITSLIQHQRIHTGEKPYQCDECGKAFRQRSDLSKHQRIHNR 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	9/43 (21%)
		COG5048	<297..451	CDD:227381	62/193 (32%)
		C2H2 Zn finger	307..327	CDD:275368	10/19 (53%)
		C2H2 Zn finger	335..355	CDD:275368	8/47 (17%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	55/135 (41%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZSCAN12	NP_001156863.1	SCAN	42..152	CDD:128708	31/126 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..175		1/20 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..264		7/68 (10%)
		C2H2 Zn finger	248..268	CDD:275368	3/21 (14%)
		C2H2 Zn finger	276..296	CDD:275368	3/19 (16%)
		COG5048	299..579	CDD:227381	97/282 (34%)
		C2H2 Zn finger	304..324	CDD:275368	3/21 (14%)
		C2H2 Zn finger	332..352	CDD:275368	10/19 (53%)
		C2H2 Zn finger	360..380	CDD:275368	4/19 (21%)
		C2H2 Zn finger	388..408	CDD:275368	1/19 (5%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		C2H2 Zn finger	444..463	CDD:275368	5/19 (26%)
		C2H2 Zn finger	471..491	CDD:275368	8/19 (42%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	527..547	CDD:275368	9/19 (47%)
		C2H2 Zn finger	555..575	CDD:275368	8/19 (42%)
		C2H2 Zn finger	583..603	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910